Robert C Hackman
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Explore the profile of Robert C Hackman including associated specialties, affiliations and a list of published articles.
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33
Citations
1609
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Recent Articles
1.
Hulverson M, Choi R, Schaefer D, Betzer D, McCloskey M, Whitman G, et al.
Antimicrob Agents Chemother
. 2023 Mar;
67(4):e0142522.
PMID: 36920244
Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and...
2.
Choi R, Hulverson M, Huang W, Vidadala R, Whitman G, Barrett L, et al.
Int J Parasitol
. 2020 Apr;
50(5):413-422.
PMID: 32224121
Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as...
3.
Huang W, Hulverson M, Choi R, Arnold S, Zhang Z, McCloskey M, et al.
J Med Chem
. 2019 Mar;
62(6):3135-3146.
PMID: 30830766
Cryptosporidium is a leading cause of pediatric diarrhea worldwide. Currently, there is neither a vaccine nor a consistently effective drug available for this disease. Selective 5-aminopyrazole-4-carboxamide-based bumped-kinase inhibitors (BKIs) are...
4.
Hulverson M, Choi R, Arnold S, Schaefer D, Hemphill A, McCloskey M, et al.
Int J Parasitol
. 2017 Sep;
47(12):753-763.
PMID: 28899690
Improvements have been made to the safety and efficacy of bumped kinase inhibitors, and they are advancing toward human and animal use for treatment of cryptosporidiosis. As the understanding of...
5.
Seo S, Waghmare A, Scott E, Xie H, Kuypers J, Hackman R, et al.
Haematologica
. 2017 Feb;
102(6):1120-1130.
PMID: 28183847
Human rhinoviruses are the most common respiratory viruses detected in patients after hematopoietic cell transplantation. Although rhinovirus appears to occasionally cause severe lower respiratory tract infection in immunocompromised patients, the...
6.
Seo S, Renaud C, Kuypers J, Chiu C, Huang M, Samayoa E, et al.
Blood
. 2015 Apr;
125(24):3789-97.
PMID: 25918347
Newer diagnostic methods may link more idiopathic pneumonia syndrome (IPS) cases to an infectious agent. Bronchoalveolar lavage (BAL) samples from 69 hematopoietic cell transplant (HCT) recipients with IPS diagnosed between...
7.
Mielcarek M, Kirkorian A, Hackman R, Price J, Storer B, Wood B, et al.
Transplantation
. 2014 Apr;
98(5):563-8.
PMID: 24717220
Background: Langerhans cells (LCs) are self-renewing epidermal myeloid cells that can migrate and mature into dendritic cells. Recipient LCs that survive cytotoxic therapy given in preparation for allogeneic hematopoietic cell...
8.
Lord J, Hackman R, Gooley T, Wood B, Moklebust A, Hockenbery D, et al.
Biol Blood Marrow Transplant
. 2010 Sep;
17(4):486-96.
PMID: 20870026
Previous studies suggest regulatory T cells (Tregs) inhibit graft-versus-host disease (GVHD) in mouse and human hematopoietic cell transplant (HCT) recipients. As the gastrointestinal tract represents one of the most common...
9.
Berger C, Berger M, Hackman R, Gough M, Elliott C, Jensen M, et al.
Blood
. 2009 Jul;
114(12):2417-26.
PMID: 19605850
The administration of cytokines that modulate endogenous or transferred T-cell immunity could improve current approaches to clinical immunotherapy. Interleukin-2 (IL-2) is used most commonly for this purpose, but causes systemic...
10.
Lord J, Hackman R, Moklebust A, Thompson J, Higano C, Chielens D, et al.
Dig Dis Sci
. 2009 Jun;
55(5):1396-405.
PMID: 19507029
Ipilimumab is a humanized antibody to CTLA4 and is used to treat cancers refractory to conventional treatment. We treated 21 patients with refractory melanoma or prostate cancer with anti-CTLA4 antibody...