Grant R Whitman
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Explore the profile of Grant R Whitman including associated specialties, affiliations and a list of published articles.
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28
Citations
317
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Recent Articles
1.
Waldron-Young E, Wijitrmektong W, Choi R, Whitman G, Hulverson M, Charania R, et al.
Mol Biochem Parasitol
. 2024 Jun;
260:111637.
PMID: 38901801
The protozoan protein kinase calcium-dependent protein kinase 1 (CDPK1) has emerged as a potential therapeutic target for the treatment of cryptosporidiosis. A focused screen of known kinase inhibitors identified a...
2.
Uo T, Ojo K, Sprenger C, Epilepsia K, Perera B, Damodarasamy M, et al.
Mol Cancer Ther
. 2024 Mar;
23(7):973-994.
PMID: 38507737
Metastatic castration-resistant prostate cancer remains incurable regardless of recent therapeutic advances. Prostate cancer tumors display highly glycolytic phenotypes as the cancer progresses. Nonspecific inhibitors of glycolysis have not been utilized...
3.
Uo T, Ojo K, Sprenger C, Epilepsia K, Perera B, Damodarasamy M, et al.
bioRxiv
. 2023 Jul;
PMID: 37461469
Purpose: Metastatic castration-resistant prostate cancer remains incurable regardless of recent therapeutic advances. Prostate cancer tumors display highly glycolytic phenotypes as the cancer progresses. Non-specific inhibitors of glycolysis have not been...
4.
Hulverson M, Choi R, Schaefer D, Betzer D, McCloskey M, Whitman G, et al.
Antimicrob Agents Chemother
. 2023 Mar;
67(4):e0142522.
PMID: 36920244
Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and...
5.
Shapiro A, Olson A, Kidoguchi L, Niu X, Ngcobo Z, Magcaba Z, et al.
J Clin Microbiol
. 2022 Aug;
60(8):e0043122.
PMID: 35913145
Testing for mycobacterial lipoarabinomannan (LAM) in urine is a practical but insensitive alternative to sputum testing to diagnose tuberculosis (TB) in people with HIV (PWH). Here, we evaluated urine LAM...
6.
Michaels S, Hulverson M, Whitman G, Tran L, Choi R, Fan E, et al.
Antimicrob Agents Chemother
. 2022 Jun;
66(7):e0001722.
PMID: 35703552
A phenotypic screen of the ReFRAME compound library was performed to identify cell-active inhibitors that could be developed as therapeutics for giardiasis. A primary screen against Giardia lamblia GS clone...
7.
Sanchez-Sanchez R, Ferre I, Re M, Perez-Arroyo B, Cleofe-Resta D, Garcia V, et al.
Int J Parasitol Drugs Drug Resist
. 2021 Oct;
17:176-185.
PMID: 34655903
The Neospora caninum Calcium-dependent protein kinase 1 (NcCDPK1) inhibitor BKI-1294 had demonstrated excellent efficacy in a pregnant mouse model of neosporosis, and was also highly efficacious in a pregnant sheep...
8.
Anghel N, Imhof D, Winzer P, Balmer V, Ramseier J, Haenggeli K, et al.
Int J Parasitol Drugs Drug Resist
. 2021 Sep;
17:92-106.
PMID: 34482255
The apicomplexan parasite Neospora caninum is an important causative agent of congenital neosporosis, resulting in abortion, birth of weak offspring and neuromuscular disorders in cattle, sheep, and many other species....
9.
Imhof D, Anghel N, Winzer P, Balmer V, Ramseier J, Hanggeli K, et al.
Int J Parasitol Drugs Drug Resist
. 2021 May;
16:90-101.
PMID: 34030110
Bumped kinase inhibitors (BKIs) target the apicomplexan calcium-dependent protein kinase 1 (CDPK1). BKI-1748, a 5-aminopyrazole-4-carboxamide compound when added to fibroblast cells concomitantly to the time of infection, inhibited proliferation of...
10.
Hulverson M, Choi R, McCloskey M, Whitman G, Ojo K, Michaels S, et al.
ACS Infect Dis
. 2021 Mar;
7(5):1275-1282.
PMID: 33740373
New drugs are critically needed to treat infections, particularly for malnourished children under 2 years old in the developing world and persons with immunodeficiencies. Bioactive compounds from the Tres-Cantos GSK...