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Robert C A M van Waardenburg

Explore the profile of Robert C A M van Waardenburg including associated specialties, affiliations and a list of published articles. Areas
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Articles 32
Citations 446
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Recent Articles
1.
van Waardenburg R
Cancer Lett . 2024 Sep; 604:217222. PMID: 39245264
No abstract available.
2.
van Waardenburg R, Falany C
Genes (Basel) . 2024 Jul; 15(7). PMID: 39062693
Cytosolic sulfotransferases (SULTs) are Phase 2 drug-metabolizing enzymes that catalyze the conjugation of sulfonate to endogenous and xenobiotic compounds, increasing their hydrophilicity and excretion from cells. To date, 13 human...
3.
Miller A, Fehling S, Vance R, Chen D, Brown E, Hossain M, et al.
Cancer Lett . 2024 May; 592:216919. PMID: 38704133
Efforts to develop targetable molecular bases for drug resistance for pancreatic ductal adenocarcinoma (PDAC) have been equivocally successful. Using RNA-seq and ingenuity pathway analysis we identified that the superpathway of...
4.
Brettrager E, Frederick A, van Waardenburg R
DNA Cell Biol . 2024 Apr; 43(7):353-361. PMID: 38682313
is a genetically tractable, affordable, and extensively documented eukaryotic single-cell model organism. This budding yeast is amenable for the development of genetic and biochemical experiments and is frequently used to...
5.
Falany C, Garcia P, Hossain M, van Waardenburg R
Methods Enzymol . 2023 Oct; 689:332-352. PMID: 37802577
Conjugation of steroids and sterol compounds with a sulfonate group is a major pathway in the regulation of their activity, synthesis and excretion. Three human cytosolic sulfotransferases are highly involved...
6.
Brettrager E, Cuya S, Tibbs Z, Zhang J, Falany C, Aller S, et al.
Sci Rep . 2023 Jan; 13(1):1377. PMID: 36697463
Tyrosyl-DNA phosphodiesterase I (Tdp1) hydrolyzes phosphodiester-linked adducts from both ends of DNA. This includes the topoisomerase I (TOP1)-DNA covalent reaction intermediate that is the target of the camptothecin class of...
7.
Garcia P, Miller A, Zeng L, van Waardenburg R, Yang E, Yoon K
Front Oncol . 2022 Jul; 12:925718. PMID: 35795040
We reported previously that the BET inhibitor (BETi) JQ1 decreases levels of the DNA repair protein RAD51 and that this decrease is concomitant with increased levels of DNA damage. Based...
8.
Brettrager E, Meehan A, Falany C, van Waardenburg R
Sci Rep . 2022 Feb; 12(1):1625. PMID: 35102205
Sulfotransferase 4A1 (SULT4A1) is an orphan member of the cytosolic SULT superfamily that contains enzymes that catalyze the sulfonation of hydrophobic drugs and hormones. SULT4A1 has been assessed through all...
9.
van Waardenburg R, Yang E
Cancer Drug Resist . 2021 Sep; 4:837-841. PMID: 34532658
No abstract available.
10.
Gmeiner W, van Waardenburg R
Cancer Drug Resist . 2021 Sep; 4:758-761. PMID: 34532656
No abstract available.