Robert Brommage
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Explore the profile of Robert Brommage including associated specialties, affiliations and a list of published articles.
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42
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1422
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Recent Articles
11.
Brommage R, Powell D, Vogel P
Dis Model Mech
. 2019 May;
12(5).
PMID: 31064765
Two large-scale mouse gene knockout phenotyping campaigns have provided extensive data on the functions of thousands of mammalian genes. The ongoing International Mouse Phenotyping Consortium (IMPC), with the goal of...
12.
Brommage R, Liu J, Vogel P, Mseeh F, Thompson A, Potter D, et al.
Bone Res
. 2019 Jan;
7:2.
PMID: 30622831
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major...
13.
Brommage R, Ohlsson C
Best Pract Res Clin Endocrinol Metab
. 2018 May;
32(3):329-340.
PMID: 29779585
Increasing attention is being focused on the important contributions of cortical bone to bone strength, fractures and osteoporosis therapies. Recent progress in human genome wide association studies in combination with...
14.
Funck-Brentano T, Nilsson K, Brommage R, Henning P, Lerner U, Koskela A, et al.
J Endocrinol
. 2018 May;
238(1):13-23.
PMID: 29720540
WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for...
15.
Rozman J, Rathkolb B, Oestereicher M, Schutt C, Ravindranath A, Leuchtenberger S, et al.
Nat Commun
. 2018 Jan;
9(1):288.
PMID: 29348434
Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to characterize so-far unannotated mammalian metabolic...
16.
Comai G, Boutet A, Tanneberger K, Massa F, Rocha A, Charlet A, et al.
J Bone Miner Res
. 2018 Jan;
33(5):875-887.
PMID: 29329488
The X-linked WTX/AMER1 protein constitutes an important component of the β-catenin destruction complex that can both enhance and suppress canonical β-catenin signaling. Somatic mutations in WTX/AMER1 have been found in...
17.
Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph S, Lutter D, et al.
Cell Metab
. 2017 Sep;
26(4):620-632.e6.
PMID: 28943448
Chronic inflammation has been proposed to contribute to the pathogenesis of diet-induced obesity. However, scarce therapeutic options are available to treat obesity and the associated immunometabolic complications. Glucocorticoids are routinely...
18.
Kumar S, Rathkolb B, Sabrautzki S, Krebs S, Kemter E, Becker L, et al.
J Biomed Sci
. 2017 Aug;
24(1):57.
PMID: 28818080
Background: Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the...
19.
Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel J, Amarie O, et al.
Nat Commun
. 2017 Aug;
8(1):155.
PMID: 28761067
Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic...
20.
Sabrautzki S, A Sandholzer M, Lorenz-Depiereux B, Brommage R, Przemeck G, Vargas Panesso I, et al.
Mamm Genome
. 2016 Sep;
27(11-12):587-598.
PMID: 27671791
Animal models resembling human mutations are valuable tools to research the features of complex human craniofacial syndromes. This is the first report on a viable dominant mouse model carrying a...