Robert Brommage
Overview
Explore the profile of Robert Brommage including associated specialties, affiliations and a list of published articles.
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42
Citations
1422
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Recent Articles
1.
Powell D, Doree D, Shadoan M, Platt K, Brommage R, Vogel P, et al.
Endocrinology
. 2024 Jun;
165(8).
PMID: 38878275
Genes regulating body fat are shared with high fidelity by mice and humans, indicating that mouse knockout (KO) phenotyping might identify valuable antiobesity drug targets. Male Mrs2 magnesium transporter (Mrs2)...
2.
Brommage R, Liu J, Powell D
Bone Res
. 2023 Feb;
11(1):9.
PMID: 36808149
Mutations in SFRP4 cause Pyle's bone disease with wide metaphyses and increased skeletal fragility. The WNT signaling pathway plays important roles in determining skeletal architecture and SFRP4 is a secreted...
3.
Powell D, Doree D, DaCosta C, Platt K, Brommage R, Buhring L, et al.
Diabetes Metab Syndr Obes
. 2022 Jan;
15:45-58.
PMID: 35023939
Purpose: Humans with haploinsufficiency of , an orphan GPCR, are thin. knockout (KO) mice are also thin with improved glucose homeostasis. We wanted to confirm these findings in KO mice...
4.
Powell D, Revelli J, Doree D, DaCosta C, Desai U, Shadoan M, et al.
Diabetes Metab Syndr Obes
. 2021 Sep;
14:3753-3785.
PMID: 34483672
Purpose: Obesity is a major public health problem. Understanding which genes contribute to obesity may better predict individual risk and allow development of new therapies. Because obesity of a mouse...
5.
Swan A, Schutt C, Rozman J, Muniz Moreno M, Brandmaier S, Simon M, et al.
PLoS Genet
. 2020 Dec;
16(12):e1009190.
PMID: 33370286
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for...
6.
Obesity of Knockout Mice Suggests That Obesity-Associated Variants Near Human Decrease G2E3 Activity
Powell D, Doree D, DaCosta C, Platt K, Hansen G, van Sligtenhorst I, et al.
Diabetes Metab Syndr Obes
. 2020 Aug;
13:2641-2652.
PMID: 32801815
Purpose: In humans, single nucleotide polymorphisms (SNPs) near the adjacent protein kinase D1 () and G2/M-phase-specific E3 ubiquitin protein ligase () genes on chromosome 14 are associated with obesity. To...
7.
Vogel P, Ding Z, Read R, DaCosta C, Hansard M, Small D, et al.
Vet Pathol
. 2020 Jul;
57(5):723-735.
PMID: 32638637
Mice with an inactivating mutation in the gene encoding asparagine synthetase domain containing 1 (ASNSD1) develop a progressive degenerative myopathy that results in severe sarcopenia and myosteatosis. ASNSD1 is conserved...
8.
Brommage R, Ohlsson C
Front Endocrinol (Lausanne)
. 2020 Mar;
10:934.
PMID: 32117046
Significance: Great progress is being made identifying mutant genes responsible for human rare genetic skeletal disorders and mouse models for genes affecting bone mass, architecture, mineralization and strength. This review...
9.
Brommage R
Handb Exp Pharmacol
. 2019 Dec;
262:451-473.
PMID: 31820174
The 11 existing FDA-approved osteoporosis drug treatments include hormone replacement therapy, 2 SERMs (raloxifene and bazedoxifene), 5 inhibitors of bone-resorbing osteoclasts (4 bisphosphonates and anti-RANKL denosumab), 2 parathyroid hormone analogues...
10.
Brommage R, Jeter-Jones S, Xiong W, Liu J
Bone
. 2019 Aug;
145:115040.
PMID: 31437568
Hip fractures at the femoral neck are a major cause of morbidity and mortality, but aside from biomechanical strength testing, little is known about femoral neck architecture in mice. Procedures...