Robert Benezra
Overview
Explore the profile of Robert Benezra including associated specialties, affiliations and a list of published articles.
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Articles
77
Citations
5638
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Recent Articles
1.
Deng Z, Loyher P, Lazarov T, Li L, Shen Z, Bhinder B, et al.
Nature
. 2024 Feb;
626(8000):864-873.
PMID: 38326607
Macrophage activation is controlled by a balance between activating and inhibitory receptors, which protect normal tissues from excessive damage during infection but promote tumour growth and metastasis in cancer. Here...
2.
Zhang N, Subbaramaiah K, Yantiss R, Zhou X, Chin Y, Benezra R, et al.
Cancer Prev Res (Phila)
. 2022 Jun;
15(6):407.
PMID: 35652224
No abstract available.
3.
Wojnarowicz P, Escolano M, Huang Y, Desai B, Chin Y, Shah R, et al.
NPJ Breast Cancer
. 2021 May;
7(1):58.
PMID: 34031428
ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and sustaining proliferation. A small-molecule, AGX51, targets ID proteins for...
4.
Song M, Wang C, Wang H, Zhang T, Li J, Benezra R, et al.
Oncoimmunology
. 2020 May;
9(1):1746148.
PMID: 32363114
UBR5 is a nuclear phosphoprotein of obscure functions. Clinical analyses reveal that amplifications and overexpression occur in over 20% cases of human breast cancers. Breast cancer patients carrying genetic lesions...
5.
Subbaramaiah K, Benezra R, Hudis C, Dannenberg A
J Biol Chem
. 2020 Jan;
295(1):296.
PMID: 31900378
No abstract available.
6.
Wojnarowicz P, Lima E Silva R, Ohnaka M, Lee S, Chin Y, Kulukian A, et al.
Cell Rep
. 2019 Oct;
29(1):62-75.e7.
PMID: 31577956
Id helix-loop-helix (HLH) proteins (Id1-4) bind E protein bHLH transcription factors, preventing them from forming active transcription complexes that drive changes in cell states. Id proteins are primarily expressed during...
7.
Cook P, Thomas R, Kannan R, Sanchez de Leon E, Drilon A, Rosenblum M, et al.
Nat Commun
. 2018 Mar;
9:16187.
PMID: 29532792
This corrects the article DOI: 10.1038/ncomms15987.
8.
Thomas R, Marks D, Chin Y, Benezra R
EMBO J
. 2017 Dec;
37(2):201-218.
PMID: 29196303
Whole chromosome gains or losses (aneuploidy) are a hallmark of ~70% of human tumors. Modeling the consequences of aneuploidy has relied on perturbing spindle assembly checkpoint (SAC) components, but interpretations...
9.
Comen E, Wojnarowicz P, Seshan V, Shah R, Coker C, Norton L, et al.
NPJ Breast Cancer
. 2017 Jul;
2:16009.
PMID: 28721376
We have previously shown a novel antimetastatic role for neutrophils in the premetastatic lung of mice in models of breast cancer. Here we expand on those findings in the context...
10.
Kleppe M, Comen E, Wen H, Bastian L, Blum B, Rapaport F, et al.
NPJ Breast Cancer
. 2017 Jul;
1:15005.
PMID: 28721364
Background: Malignant transformation requires the interaction of cancer cells with their microenvironment, including infiltrating leukocytes. However, somatic mutational studies have focused on alterations in cancer cells, assuming that the microenvironment...