Robert B Flint
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Explore the profile of Robert B Flint including associated specialties, affiliations and a list of published articles.
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50
Citations
260
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Recent Articles
11.
Wu Y, Voller S, Krekels E, Roofthooft D, Simons S, Tibboel D, et al.
Pharm Res
. 2023 Aug;
40(9):2155-2166.
PMID: 37603141
Purpose: Despite being off-label, intravenous paracetamol (PCM) is increasingly used to control mild-to-moderate pain in preterm neonates. Here we aim to quantify the maturation of paracetamol elimination pathways in preterm...
12.
van der Zande J, Cornette J, Roos-Hesselink J, Flint R
Int Breastfeed J
. 2023 Apr;
18(1):21.
PMID: 37060099
Background: Mothers requiring the antiarrhythmic agent flecainide are often advised not to breastfeed, because of the lack of data concercing neonatal effects and flecainide plasma concentrations following maternal exposure as...
13.
de Geus A, Koppen I, Flint R, Benninga M, Tabbers M
Paediatr Drugs
. 2023 Mar;
25(3):343-358.
PMID: 36941393
Functional constipation is a common problem in childhood worldwide and has a great impact on social, physical, and emotional functioning of affected children and their caregivers. It is a clinical...
14.
de Hoop-Sommen M, van der Zanden T, Allegaert K, Flint R, Simons S, de Wildt S
Neonatology
. 2023 Jan;
120(2):196-207.
PMID: 36646065
Methods: The selection of drugs was based on frequency of prescribing, availability of a neonatal DR in the Dutch Pediatric Formulary, and the labeling status. Clinical need, pharmacological diversity, and...
15.
Smit C, Engbers A, Samiee-Zafarghandy S, van Donge T, Simons S, Flint R, et al.
Neonatology
. 2022 Dec;
120(1):81-89.
PMID: 36502794
Introduction: Oral ibuprofen is more effective than intravenous (IV) ibuprofen for closure of a patent ductus arteriosus (PDA). This study explored whether higher concentrations of the biologically active S-enantiomer or...
16.
van de Vusse D, Mian P, Schoenmakers S, Flint R, Visser W, Allegaert K, et al.
Eur J Clin Pharmacol
. 2022 Sep;
78(11):1763-1776.
PMID: 36104450
Purpose: Antihypertensive drugs are among the most prescribed drugs during pregnancy. Methyldopa, labetalol, and nifedipine have been perceived safe to use during pregnancy and are therefore recommended in international guidelines...
17.
de Bruin R, van Dalen S, Franx S, Simons S, Flint R, van den Bosch G
BMJ Open
. 2022 Aug;
12(8):e055292.
PMID: 36008071
Introduction: Beta-blockers are often used during pregnancy to treat diseases such as pre-existing hypertension, arrhythmias or pregnancy-related hypertension. Since beta-blockers are able to cross the placenta and can pass into...
18.
de Bruin R, van Dalen S, Franx S, Ramaswamy V, Simons S, Flint R, et al.
Int J Environ Res Public Health
. 2022 Aug;
19(15).
PMID: 35954977
Beta-blockers are often used during pregnancy to treat cardiovascular diseases. The described neonatal side effects of maternal beta-blocker use are hypoglycemia and bradycardia, but the evidence base for these is...
19.
Yalcin N, Flint R, van Schaik R, Simons S, Allegaert K
Pharmgenomics Pers Med
. 2022 Jul;
15:675-696.
PMID: 35795337
In neonates, pharmacogenetics has an additional layer of complexity. This is because in addition to genetic variability in genes that code for proteins relevant to clinical pharmacology, there are rapidly...
20.
Engbers A, Voller S, Flint R, Goulooze S, de Klerk J, Krekels E, et al.
Clin Pharmacol Ther
. 2022 Apr;
112(2):307-315.
PMID: 35429165
Spontaneous closure of the ductus arteriosus depends on gestational age (GA) and might be delayed in preterm infants, resulting in patent ductus arteriosus (PDA). Ibuprofen can be administered to enhance...