Robert A Cross
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Explore the profile of Robert A Cross including associated specialties, affiliations and a list of published articles.
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40
Citations
1083
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Recent Articles
1.
Chew Y, Cross R
Biochem Soc Trans
. 2025 Feb;
53(1).
PMID: 39910801
Microtubule (MT) dynamic instability, a cycle of growth, catastrophe, shrinkage and rescue, is driven by the switching of tubulin between two structural states, one stabilised by GTP and the other...
2.
Sumiyoshi R, Yamagishi M, Furuta A, Nishizaka T, Furuta K, Cross R, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(30):e2403739121.
PMID: 39012822
Natural kinesin motors are tethered to their cargoes via short C-terminal or N-terminal linkers, whose docking against the core motor domain generates directional force. It remains unclear whether linker docking...
3.
Chew Y, Cross R
Commun Biol
. 2023 Sep;
6(1):946.
PMID: 37717119
Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice. We show here that taxol has different effects on different single-isotype microtubule lattices. Using in vitro...
4.
Sugawa M, Maruyama Y, Yamagishi M, Cross R, Yajima J
Commun Biol
. 2022 Dec;
5(1):1368.
PMID: 36539506
Kinesin motor domains generate impulses of force and movement that have both translational and rotational (torque) components. Here, we ask how the torque component influences function in cargo-attached teams of...
5.
Siddiqui N, Roth D, Toleikis A, Zwetsloot A, Cross R, Straube A
Curr Biol
. 2022 Aug;
32(17):3862-3870.e6.
PMID: 35961316
Intracellular transport is essential for neuronal function and survival. The most effective plus-end-directed neuronal transporter is the kinesin-3 KIF1C, which transports large secretory vesicles and endosomes. Mutations in KIF1C cause...
6.
Toleikis A, Carter N, Cross R
Biophys J
. 2020 Oct;
119(10):1984-1994.
PMID: 33091340
Kinesin-1 is an ATP-driven molecular motor that transports cellular cargo along microtubules. At low loads, kinesin-1 almost always steps forward, toward microtubule plus ends, but at higher loads, it can...
7.
Chew Y, Cross R
Curr Biol
. 2020 Sep;
30(17):R988-R991.
PMID: 32898497
Modern life is replete with function-expanding dongles, and life at the molecular scale is, it turns out, no exception. Hanging out of the back of the Kif14 molecular motor is...
8.
Andrecka J, Ortega Arroyo J, Lewis K, Cross R, Kukura P
Biophys J
. 2019 Jul;
110(5):1202-1203.
PMID: 31265488
[This corrects the article DOI: 10.1016/j.bpj.2015.10.055.].
9.
Cross R
Curr Opin Cell Biol
. 2018 Nov;
56:88-93.
PMID: 30415187
In classical microtubule dynamic instability, the dynamics of the built polymer depend only on the nucleotide state of its individual tubulin molecules. Recent work is overturning this view, pointing instead...
10.
Meadows J, Messin L, Kamnev A, Lancaster T, Balasubramanian M, Cross R, et al.
EMBO Rep
. 2018 Sep;
19(11).
PMID: 30206188
In fission yeast, the lengths of interphase microtubule (iMT) arrays are adapted to cell length to maintain cell polarity and to help centre the nucleus and cell division ring. Here,...