Robert A Beagrie
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Explore the profile of Robert A Beagrie including associated specialties, affiliations and a list of published articles.
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15
Citations
579
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0
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Recent Articles
1.
Beagrie R, Thieme C, Annunziatella C, Baugher C, Zhang Y, Schueler M, et al.
Nat Methods
. 2023 Jun;
20(7):1037-1047.
PMID: 37336949
Technology for measuring 3D genome topology is increasingly important for studying gene regulation, for genome assembly and for mapping of genome rearrangements. Hi-C and other ligation-based methods have become routine...
2.
Vermunt M, Luan J, Zhang Z, Thrasher A, Huang A, Saari M, et al.
Mol Cell
. 2023 Mar;
83(5):715-730.e6.
PMID: 36868189
Transcriptional enhancers have been extensively characterized, but cis-regulatory elements involved in acute gene repression have received less attention. Transcription factor GATA1 promotes erythroid differentiation by activating and repressing distinct gene...
3.
Jung M, Shen S, Botten G, Olender T, Katsumura K, Johnson K, et al.
J Clin Invest
. 2023 Feb;
133(7).
PMID: 36809258
Although certain human genetic variants are conspicuously loss of function, decoding the impact of many variants is challenging. Previously, we described a patient with leukemia predisposition syndrome (GATA2 deficiency) with...
4.
Francis H, Harold C, Beagrie R, King A, Gosden M, Blayney J, et al.
PLoS One
. 2022 Jan;
17(1):e0261950.
PMID: 34995303
Mouse embryonic stem cells (mESCs) can be manipulated in vitro to recapitulate the process of erythropoiesis, during which multipotent cells undergo lineage specification, differentiation and maturation to produce erythroid cells....
5.
Herrmann J, Beagrie R, Hughes J
Trends Genet
. 2021 Nov;
38(4):395-408.
PMID: 34753603
Deciphering the process by which hundreds of distinct cell types emerge from a single zygote to form a complex multicellular organism remains one of the greatest challenges in biological research....
6.
King A, Songdej D, Downes D, Beagrie R, Liu S, Buckley M, et al.
Nat Commun
. 2021 Jul;
12(1):4439.
PMID: 34290235
The α- and β-globin loci harbor developmentally expressed genes, which are silenced throughout post-natal life. Reactivation of these genes may offer therapeutic approaches for the hemoglobinopathies, the most common single...
7.
Enhancers predominantly regulate gene expression during differentiation via transcription initiation
Larke M, Schwessinger R, Nojima T, Telenius J, Beagrie R, Downes D, et al.
Mol Cell
. 2021 Feb;
81(5):983-997.e7.
PMID: 33539786
Gene transcription occurs via a cycle of linked events, including initiation, promoter-proximal pausing, and elongation of RNA polymerase II (Pol II). A key question is how transcriptional enhancers influence these...
8.
Downes D, Beagrie R, Gosden M, Telenius J, Carpenter S, Nussbaum L, et al.
Nat Commun
. 2021 Jan;
12(1):531.
PMID: 33483495
Chromosome conformation capture (3C) provides an adaptable tool for studying diverse biological questions. Current 3C methods generally provide either low-resolution interaction profiles across the entire genome, or high-resolution interaction profiles...
9.
Oudelaar A, Beagrie R, Kassouf M, Higgs D
Curr Opin Genet Dev
. 2020 Nov;
67:18-24.
PMID: 33221670
The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood...
10.
Miar A, Arnaiz E, Bridges E, Beedie S, Cribbs A, Downes D, et al.
Cancer Res
. 2020 Oct;
80(23):5245-5256.
PMID: 33115807
Hypoxia is a common phenomenon in solid tumors and is strongly linked to hallmarks of cancer. Recent evidence has shown that hypoxia promotes local immune suppression. Type I IFN supports...