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Rithy Meas

Explore the profile of Rithy Meas including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 148
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Recent Articles
1.
Meas R, Nititham J, Taylor K, Maher S, Clairmont K, Carufe K, et al.
ACR Open Rheumatol . 2022 Jun; 4(9):760-770. PMID: 35708944
Objective: To determine if single-nucleotide polymorphisms (SNPs) in DNA repair genes are enriched in individuals with systemic lupus erythematosus (SLE) and if they are sufficient to confer a disease phenotype...
2.
Rahim T, Levinson M, Carufe K, Burak M, Meas R, Maher S, et al.
PLoS One . 2022 Apr; 17(4):e0267913. PMID: 35486639
Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of...
3.
Paluri S, Burak M, Senejani A, Levinson M, Rahim T, Clairmont K, et al.
DNA Repair (Amst) . 2021 Jun; 105:103152. PMID: 34186496
The Polb gene encodes DNA polymerase beta (Pol β), a DNA polymerase that functions in base excision repair (BER) and microhomology-mediated end-joining. The Pol β-Y265C protein exhibits low catalytic activity...
4.
Alvarado-Cruz I, Mahmoud M, Khan M, Zhao S, Oeck S, Meas R, et al.
Biochem Pharmacol . 2020 Dec; 184:114359. PMID: 33285109
Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors (PARPi) have been suggested to act by...
5.
Alvarado-Cruz I, Meas R, Paluri S, Carufe K, Khan M, Sweasy J
Mutagenesis . 2019 Dec; 35(1):69-78. PMID: 31880305
Defects in DNA repair have been linked to the accumulation of somatic mutations in tumours. These mutations can promote oncogenesis; however, recent developments have indicated that they may also lead...
6.
Meas R, Wyrick J, Smerdon M
Mutat Res Rev Mutat Res . 2019 Aug; 780:29-36. PMID: 31388331
Chromatin is a significant barrier to many DNA damage response (DDR) factors, such as DNA repair enzymes, that process DNA lesions to reduce mutations and prevent cell death; yet, paradoxically,...
7.
Meas R, Burak M, Sweasy J
DNA Repair (Amst) . 2017 Jun; 56:174-182. PMID: 28623091
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with no known cure that affects at least five million people worldwide. Monozygotic twin concordance and familial aggregation studies strongly suggest...
8.
Meas R, Smerdon M
Sci Rep . 2016 Jun; 6:27122. PMID: 27265863
Base excision repair (BER) processes non-helix distorting lesions (e.g., uracils and gaps) and is composed of two subpathways that differ in the number of nucleotides (nts) incorporated during the DNA...
9.
Meas R, Mao P
DNA Repair (Amst) . 2015 Oct; 36:36-42. PMID: 26422137
DNA in human cells is constantly assaulted by endogenous and exogenous DNA damaging agents. It is vital for the cell to respond rapidly and precisely to DNA damage to maintain...
10.
Hodges A, Gallegos I, Laughery M, Meas R, Tran L, Wyrick J
Genetics . 2015 May; 200(3):795-806. PMID: 25971662
A critical feature of the intermolecular contacts that bind DNA to the histone octamer is the series of histone arginine residues that insert into the DNA minor groove at each...