Alfred L M Bothwell
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Explore the profile of Alfred L M Bothwell including associated specialties, affiliations and a list of published articles.
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83
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2075
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Recent Articles
1.
Kim J, Park S, Kim J, Kim Y, Yoon H, Rayhan B, et al.
Exp Mol Med
. 2024 Dec;
57(1):1-12.
PMID: 39741180
Trogocytosis is a dynamic cellular process characterized by the exchange of the plasma membrane and associated cytosol during cell-to-cell interactions. Unlike phagocytosis, this transfer maintains the surface localization of transferred...
2.
Shin J, Park J, Lim J, Jeong J, Dinesh R, Maher S, et al.
Elife
. 2024 Nov;
13.
PMID: 39535280
Metastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear....
3.
Ihedioha O, Marcarian H, Sivakoses A, Beverley S, McMahon-Pratt D, Bothwell A
Front Immunol
. 2024 Nov;
15:1473133.
PMID: 39502693
Background: Host-related factors highly regulate the increased circulation of neutrophils during infection. Platelet-derived Dickkopf-1 (DKK1) is established as a high-affinity ligand to LRP6. Recently, we demonstrated that DKK1 upregulates leukocyte-platelet...
4.
Sivakoses A, Marcarian H, Arias A, Lam A, Ihedioha O, Santamaria J, et al.
bioRxiv
. 2024 Aug;
PMID: 39211230
Teaser: TNBC cells acquire small spherical structures from T cells containing lymphocyte-specific membrane proteins and genomic DNA.
5.
Marcarian H, Sivakoses A, Arias A, Ihedioha O, Bishop M, Lee B, et al.
bioRxiv
. 2024 Aug;
PMID: 39211212
Trogocytosis is an underappreciated phenomenon that shapes the immune microenvironment surrounding many types of solid tumors. The consequences of membrane-bound proteins being deposited from a donor immune cell to a...
6.
Shin J, Park J, Lim J, Jeong J, Dinesh R, Maher S, et al.
bioRxiv
. 2024 Apr;
PMID: 38659853
Metastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear....
7.
Ihedioha O, Sivakoses A, Beverley S, McMahon-Pratt D, Bothwell A
Front Immunol
. 2023 Oct;
14:1257046.
PMID: 37885890
Background: Platelets are rapidly deployed to infection sites and respond to pathogenic molecules via pattern recognition receptors (TLR, NLRP). Dickkopf1 (DKK1) is a quintessential Wnt antagonist produced by a variety...
8.
Rahim T, Levinson M, Carufe K, Burak M, Meas R, Maher S, et al.
PLoS One
. 2022 Apr;
17(4):e0267913.
PMID: 35486639
Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of...
9.
Lee S, Cavaliere A, Gallezot J, Keler T, Michelhaugh S, Belitzky E, et al.
Mol Cancer Ther
. 2022 Jan;
21(3):440-447.
PMID: 35027482
There is a need for prognostic markers to select patients most likely to benefit from antibody-drug conjugate (ADC) therapy. We quantified the relationship between pretreatment PET imaging of glycoprotein nonmetastatic...
10.
Park M, Shin J, Bothwell A, Chae W
J Leukoc Biol
. 2021 Dec;
111(4):893-901.
PMID: 34890067
The human body encounters various challenges. Tissue repair and regeneration processes are augmented after tissue injury to reinstate tissue homeostasis. The Wnt pathway plays a crucial role in tissue repair...