Rima Darwiche
Overview
Explore the profile of Rima Darwiche including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
439
Followers
0
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Recent Articles
1.
Angstetra E, Graham K, Emmett S, Dudek N, Darwiche R, Ayala-Perez R, et al.
Immunol Cell Biol
. 2008 Nov;
87(2):178-85.
PMID: 19015667
CD4(+) T cells can actively kill beta-cells in type I diabetes as well as help CD8(+) T cells become cytolytic. Cytokines have the potential to kill beta-cells, or upregulate Fas...
2.
Barral A, Thomas H, Ling E, Darwiche R, Rodrigo E, Christen U, et al.
J Autoimmun
. 2006 Oct;
27(3):166-73.
PMID: 17045460
CD8(+) cytotoxic T lymphocytes (CTL) can rapidly kill beta-cells and therefore contribute to the development of type 1 diabetes (T1D). CTL-mediated beta-cell killing can occur via perforin-mediated lysis, Fas-Fas-L interaction,...
3.
Chen Y, Chong M, Darwiche R, Thomas H, Kay T
Am J Pathol
. 2004 Aug;
165(3):913-21.
PMID: 15331415
Mice with suppressor of cytokine signaling-1 (SOCS-1) deficiency die within 3 weeks of birth from a multiorgan inflammatory disease. Increased systemic levels and sensitivity of cells to the inflammatory cytokines...
4.
Chong M, Chen Y, Darwiche R, Dudek N, Irawaty W, Santamaria P, et al.
J Immunol
. 2004 Apr;
172(9):5714-21.
PMID: 15100317
In type 1 diabetes, cytokine action on beta cells potentially contributes to beta cell destruction by direct cytotoxicity, inducing Fas expression, and up-regulating class I MHC and chemokine expression to...
5.
Christen U, Darwiche R, Thomas H, Wolfe T, Rodrigo E, Chervonsky A, et al.
Diabetes
. 2004 Feb;
53(3):591-6.
PMID: 14988242
Tissue-specific expression of Fas-ligand (Fas-L) can provide immune privilege by inducing apoptosis of "invading" lymphocytes expressing Fas. However, accelerated diabetes has been reported in transgenic mice expressing Fas-L in islets...
6.
Thomas H, Irawaty W, Darwiche R, Brodnicki T, Santamaria P, Allison J, et al.
Diabetes
. 2003 Dec;
53(1):113-21.
PMID: 14693705
Proinflammatory cytokines are believed to be important in pancreatic beta-cell destruction in the development of type 1 diabetes. They act by upregulation of genes including Fas and inducible nitric oxide...
7.
Darwiche R, Chong M, Santamaria P, Thomas H, Kay T
J Immunol
. 2003 Jun;
170(12):6292-7.
PMID: 12794162
Fas (CD95) is a potential mechanism of pancreatic beta cell death in type 1 diabetes. beta cells do not constitutively express Fas but it is induced by cytokines. The hypothesis...
8.
Chong M, Cornish A, Darwiche R, Stanley E, Purton J, Godfrey D, et al.
Immunity
. 2003 Apr;
18(4):475-87.
PMID: 12705851
To determine the tissue-specific functions of SOCS-1, mice were generated in which the SOCS-1 gene could be deleted in individual tissues. A reporter gene of SOCS-1 promoter activity was also...
9.
Cornish A, Chong M, Davey G, Darwiche R, Nicola N, Hilton D, et al.
J Biol Chem
. 2003 Apr;
278(25):22755-61.
PMID: 12665516
Suppressor of cytokine signaling-1 (SOCS-1) is an essential regulator of cytokine signaling. SOCS-1-/- mice die before weaning with a complex disease characterized by fatty degeneration and necrosis of the liver....
10.
Kay T, Darwiche R, Irawaty W, Chong M, Pennington H, Thomas H
Adv Exp Med Biol
. 2003 Mar;
520:73-86.
PMID: 12613573
No abstract available.