Riikka Halmetoja
Overview
Explore the profile of Riikka Halmetoja including associated specialties, affiliations and a list of published articles.
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4
Citations
10
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0
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Recent Articles
1.
Ala-Nisula T, Halmetoja R, Leinonen H, Kurkela M, Lipponen H, Sakko S, et al.
Pflugers Arch
. 2024 Feb;
476(9):1339-1351.
PMID: 38396259
Transmembrane prolyl 4-hydroxylase (P4H-TM) is an enigmatic enzyme whose cellular function and primary substrate remain to be identified. Its loss-of-function mutations cause a severe neurological HIDEA syndrome with hypotonia, intellectual...
2.
Tapio J, Halmetoja R, Dimova E, Maki J, Laitala A, Walkinshaw G, et al.
J Biol Chem
. 2022 Jul;
298(8):102222.
PMID: 35787374
Hypoxia-inducible factor (HIF) prolyl 4-hydroxylases (HIF-P4Hs 1-3) are druggable targets in renal anemia, where pan-HIF-P4H inhibitors induce an erythropoietic response. Preclinical data suggest that HIF-P4Hs could also be therapeutic targets...
3.
Sissala N, Myllymaki E, Mohr F, Halmetoja R, Kuvaja P, Dimova E, et al.
Physiol Rep
. 2022 May;
10(9):e15302.
PMID: 35535947
Maternal overweight/obesity contributes significantly to the development of gestational diabetes, which causes risks to both mother and fetus and is increasing sharply in prevalence worldwide. Since hypoxia reprograms energy metabolism...
4.
Roning T, Magga J, Laitakari A, Halmetoja R, Tapio J, Dimova E, et al.
J Mol Cell Cardiol
. 2021 Dec;
164:148-155.
PMID: 34919895
Aims: We have previously demonstrated protection against obesity, metabolic dysfunction, atherosclerosis and cardiac ischemia in a hypoxia-inducible factor (HIF) prolyl 4-hydroxylase-2 (Hif-p4h-2) deficient mouse line, attributing these protective effects to...