Johanna Myllyharju
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Explore the profile of Johanna Myllyharju including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Norman O, Koivunen J, Kaarteenaho R, Salo A, Maki J, Myllyharju J, et al.
BMJ Open Respir Res
. 2024 Apr;
10(1).
PMID: 38568728
Background: Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties....
2.
Ala-Nisula T, Halmetoja R, Leinonen H, Kurkela M, Lipponen H, Sakko S, et al.
Pflugers Arch
. 2024 Feb;
476(9):1339-1351.
PMID: 38396259
Transmembrane prolyl 4-hydroxylase (P4H-TM) is an enigmatic enzyme whose cellular function and primary substrate remain to be identified. Its loss-of-function mutations cause a severe neurological HIDEA syndrome with hypotonia, intellectual...
3.
Salo A, Rappu P, Koski M, Karjalainen E, Izzi V, Drushinin K, et al.
Matrix Biol
. 2023 Dec;
125:73-87.
PMID: 38081527
Collagen biosynthesis requires several co- and post-translational modifications of lysine and proline residues to form structurally and functionally competent collagen molecules. Formation of 4-hydroxyproline (4Hyp) in Y-position prolines of the...
4.
Murthy A, Sulu R, Lebedev A, Salo A, Korhonen K, Venkatesan R, et al.
J Biol Chem
. 2022 Oct;
298(12):102614.
PMID: 36265586
Collagen prolyl 4-hydroxylases (C-P4H) are αβ tetramers, which catalyze the prolyl 4-hydroxylation of procollagen, allowing for the formation of the stable triple-helical collagen structure in the endoplasmic reticulum. The C-P4H...
5.
Ollonen T, Kurkela M, Laitakari A, Sakko S, Koivisto H, Myllyharju J, et al.
Cell Mol Life Sci
. 2022 Jul;
79(8):432.
PMID: 35852609
Alzheimer's disease (AD) is the most common cause of dementia with limited treatment options affecting millions of people and the prevalence increasing with the aging population. The current knowledge on...
6.
Tapio J, Halmetoja R, Dimova E, Maki J, Laitala A, Walkinshaw G, et al.
J Biol Chem
. 2022 Jul;
298(8):102222.
PMID: 35787374
Hypoxia-inducible factor (HIF) prolyl 4-hydroxylases (HIF-P4Hs 1-3) are druggable targets in renal anemia, where pan-HIF-P4H inhibitors induce an erythropoietic response. Preclinical data suggest that HIF-P4Hs could also be therapeutic targets...
7.
Tolonen J, Salo A, Finnila M, Aro E, Karjalainen E, Ronkainen V, et al.
JBMR Plus
. 2022 Jun;
6(6):e10630.
PMID: 35720665
Proper deposition of the extracellular matrix and its major components, the collagens, is essential for endochondral ossification and bone mass accrual. Collagen prolyl 4-hydroxylases (C-P4Hs) hydroxylate proline residues in the...
8.
Rosendahl A, Monnius M, Laitala A, Railo A, Miinalainen I, Heljasvaara R, et al.
J Biol Chem
. 2022 Mar;
298(4):101787.
PMID: 35247391
Hypoxia-inducible factors (HIFs) induce numerous genes regulating oxygen homeostasis. As oxygen sensors of the cells, the HIF prolyl 4-hydroxylases (HIF-P4Hs) regulate the stability of HIFs in an oxygen-dependent manner. During...
9.
Byts N, Sharma S, Malm T, Kaakinen M, Korhonen P, Jaakkonen L, et al.
J Biol Chem
. 2022 Feb;
298(3):101721.
PMID: 35151685
Hypoxia-inducible factor prolyl 4-hydroxylases (HIF-P4Hs) regulate the hypoxic induction of >300 genes required for survival and adaptation under oxygen deprivation. Inhibition of HIF-P4H-2 has been shown to be protective in...
10.
Elamaa H, Kaakinen M, Natynki M, Szabo Z, Ronkainen V, Aijala V, et al.
Angiogenesis
. 2022 Jan;
25(2):259-274.
PMID: 34997404
Hypoxia plays an important regulatory role in the vasculature to adjust blood flow to meet metabolic requirements. At the level of gene transcription, the responses are mediated by hypoxia-inducible factor...