Richard Wooster
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Explore the profile of Richard Wooster including associated specialties, affiliations and a list of published articles.
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61
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13320
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Recent Articles
1.
Woo C, Allawzi A, Clark N, Kaushal N, Efthymiou T, Thamsen M, et al.
Pulm Pharmacol Ther
. 2022 May;
75:102134.
PMID: 35613658
Primary ciliary dyskinesia (PCD) is a respiratory disease caused by dysfunction of the cilia with currently no approved treatments. This predominantly autosomal recessive disease is caused by mutations in any...
2.
Barbier A, Jiang A, Zhang P, Wooster R, Anderson D
Nat Biotechnol
. 2022 May;
40(6):840-854.
PMID: 35534554
The emergency use authorizations (EUAs) of two mRNA-based severe acute respiratory syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after publication of the viral sequence highlights the transformative potential of this...
3.
Perino S, Moreau B, Freda J, Cirello A, White B, Quinn J, et al.
Mol Cancer Ther
. 2020 Jun;
19(8):1613-1622.
PMID: 32499300
The PI3K pathway is considered a master regulator for cancer due to its frequent activation, making it an attractive target for pharmacologic intervention. While substantial efforts have been made to...
4.
Whalen K, White B, Quinn J, Kriksciukaite K, Alargova R, Au Yeung T, et al.
Mol Cancer Ther
. 2019 Oct;
18(11):1926-1936.
PMID: 31649014
Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma with a 95% mortality rate with no improvement to treatment in decades, and new therapies are desperately needed. PEN-221 is...
5.
White B, Whalen K, Kriksciukaite K, Alargova R, Au Yeung T, Bazinet P, et al.
J Med Chem
. 2019 Feb;
62(5):2708-2719.
PMID: 30735385
Somatostatin receptor 2 (SSTR2) is frequently overexpressed on several types of solid tumors, including neuroendocrine tumors and small-cell lung cancer. Peptide agonists of SSTR2 are rapidly internalized upon binding to...
6.
Hu Z, Mao J, Curtis C, Huang G, Gu S, Heiser L, et al.
Breast Cancer Res
. 2017 Feb;
19(1):17.
PMID: 28183333
No abstract available.
7.
Shi J, Kantoff P, Wooster R, Farokhzad O
Nat Rev Cancer
. 2016 Nov;
17(1):20-37.
PMID: 27834398
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological...
8.
Hu Z, Mao J, Curtis C, Huang G, Gu S, Heiser L, et al.
Breast Cancer Res
. 2016 Jul;
18(1):70.
PMID: 27368372
Background: High mitotic activity is associated with the genesis and progression of many cancers. Small molecule inhibitors of mitotic apparatus proteins are now being developed and evaluated clinically as anticancer...
9.
Zhu X, Qin X, Fei M, Hou W, Greshock J, Bachman K, et al.
Int J Mol Sci
. 2012 Sep;
13(8):9980-9991.
PMID: 22949843
We aimed to investigate the expression pattern of phosphatase and tensin homolog (PTEN), to evaluate the relationship between PTEN expression and clinicopathological characteristics, including fatty acid synthase (FAS) expression, and...
10.
Mayes P, Degenhardt Y, Wood A, Toporovskya Y, Diskin S, Haglund E, et al.
Int J Cancer
. 2012 Sep;
132(3):E149-57.
PMID: 22948716
Inhibition of centromere-associated protein-E (CENP-E) has demonstrated preclinical anti-tumor activity in a number of tumor types including neuroblastoma. A potent small molecule inhibitor of the kinesin motor activity of CENP-E...