Richard T Pomerantz
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Explore the profile of Richard T Pomerantz including associated specialties, affiliations and a list of published articles.
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42
Citations
1351
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Recent Articles
11.
Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert M, Tredinnick T, et al.
Nat Struct Mol Biol
. 2023 Apr;
30(7):1048.
PMID: 37059901
No abstract available.
12.
Vekariya U, Toma M, Nieborowska-Skorska M, Le B, Caron M, Kukuyan A, et al.
Blood
. 2022 Dec;
141(19):2372-2389.
PMID: 36580665
Leukemia cells accumulate DNA damage, but altered DNA repair mechanisms protect them from apoptosis. We showed here that formaldehyde generated by serine/1-carbon cycle metabolism contributed to the accumulation of toxic...
13.
Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert M, Tredinnick T, et al.
Nat Struct Mol Biol
. 2022 Dec;
30(1):107-114.
PMID: 36536104
The double-strand break (DSB) repair pathway called microhomology-mediated end-joining (MMEJ) is thought to be dependent on DNA polymerase theta (Polθ) and occur independently of nonhomologous end-joining (NHEJ) factors. An unresolved...
14.
Chen X, Pomerantz R
Genes (Basel)
. 2021 Aug;
12(8).
PMID: 34440316
The emergence of precision medicine from the development of Poly (ADP-ribose) polymerase (PARP) inhibitors that preferentially kill cells defective in homologous recombination has sparked wide interest in identifying and characterizing...
15.
Chandramouly G, Zhao J, McDevitt S, Rusanov T, Hoang T, Borisonnik N, et al.
Sci Adv
. 2021 Jun;
7(24).
PMID: 34117057
Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. Whether mammalian DNA repair Pols efficiently use template ribonucleotides and promote RNA-templated DNA repair synthesis remains unknown. We find...
16.
Chandramouly G, Liao S, Rusanov T, Borisonnik N, Calbert M, Kent T, et al.
Cell Rep
. 2021 Mar;
34(10):108820.
PMID: 33691100
DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by...
17.
Black S, Ozdemir A, Kashkina E, Kent T, Rusanov T, Ristic D, et al.
Nat Commun
. 2020 Apr;
11(1):1831.
PMID: 32273507
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
18.
Black S, Ozdemir A, Kashkina E, Kent T, Rusanov T, Ristic D, et al.
Nat Commun
. 2019 Sep;
10(1):4423.
PMID: 31562312
DNA polymerase θ (Polθ) is a unique polymerase-helicase fusion protein that promotes microhomology-mediated end-joining (MMEJ) of DNA double-strand breaks (DSBs). How full-length human Polθ performs MMEJ at the molecular level...
19.
Thomas C, Rusanov T, Hoang T, Augustin T, Kent T, Gaspar I, et al.
Nucleic Acids Res
. 2019 Mar;
47(7):3272-3283.
PMID: 30818397
Site-specific modification of synthetic and cellular RNA such as with specific nucleobases, fluorophores and attachment chemistries is important for a variety of basic and applied research applications. However, simple and...
20.
Rusanov T, Kent T, Saeed M, Hoang T, Thomas C, Rice C, et al.
Sci Rep
. 2018 Nov;
8(1):17384.
PMID: 30478404
The spread of Zika virus (ZIKV) has caused an international health emergency due to its ability to cause microcephaly in infants. Yet, our knowledge of how ZIKV replicates at the...