Mike ODonnell
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Explore the profile of Mike ODonnell including associated specialties, affiliations and a list of published articles.
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Articles
108
Citations
4333
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Recent Articles
1.
Li H, ODonnell M, Kelch B
Bioessays
. 2022 Sep;
44(11):e2200154.
PMID: 36116108
Clamp loaders are pentameric AAA+ assemblies that use ATP to open and close circular DNA sliding clamps around DNA. Clamp loaders show homology in all organisms, from bacteria to human....
2.
Mayle R, ODonnell M
Methods Enzymol
. 2021 Nov;
660:3-20.
PMID: 34742395
Baker's yeast, Saccharomyces cerevisiae, is a versatile system for expression of recombinant eukaryotic proteins. This system is simple to use and does not require extraordinary expertise nor tissue culture facilities....
3.
Li H, Zheng F, ODonnell M
FEBS J
. 2021 Feb;
288(24):7256-7262.
PMID: 33523561
Polymerase sliding clamps are ring-shaped proteins that encircle duplex DNA and hold polymerases to DNA for high processivity during synthesis. The crystal structure of clamp-DNA complex reveals that the DNA...
4.
Schauer G, Finkelstein J, ODonnell M
Bio Protoc
. 2017 Oct;
7(18).
PMID: 29082290
The eukaryotic replisome is a multiprotein complex that duplicates DNA. The replisome is sculpted to couple continuous leading strand synthesis with discontinuous lagging strand synthesis, primarily carried out by DNA...
5.
6.
Langston L, ODonnell M
Elife
. 2017 Mar;
6.
PMID: 28346143
Replicative helicases are ring-shaped hexamers that encircle DNA for duplex unwinding. The currently accepted view of hexameric helicase function is by steric exclusion, where the helicase encircles one DNA strand...
7.
Yao N, ODonnell M
Curr Biol
. 2017 Mar;
27(5):R174-R176.
PMID: 28267969
DNA sliding clamps are rings that tether certain enzymes to DNA. How clamp proteins slide on DNA has remained a mystery. A new crystal structure, together with molecular dynamics and...
8.
Yao N, ODonnell M
JSM Biochem Mol Biol
. 2017 Jan;
3(1).
PMID: 28042596
Cellular genomic DNA is replicated by a multiprotein replisome machine. The replisome contains numerous essential factors that unwind, prime and synthesize each of the two strands of duplex DNA. The...
9.
Yurieva O, ODonnell M
Nucleus
. 2016 Jul;
7(4):360-8.
PMID: 27416113
Eukaryotes require 3 DNA polymerases for normal replisome operations, DNA polymerases (Pol) α, delta and epsilon. Recent biochemical and structural studies support the asymmetric use of these polymerases on the...
10.
Sun J, Yuan Z, Georgescu R, Li H, ODonnell M
Nucleus
. 2016 Jun;
7(2):146-54.
PMID: 27310307
The eukaryotic replisome is α multiprotein machine that contains DNA polymerases, sliding clamps, helicase, and primase along with several factors that participate in cell cycle and checkpoint control. The detailed...