Richard M Siegel
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Explore the profile of Richard M Siegel including associated specialties, affiliations and a list of published articles.
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109
Citations
5227
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Recent Articles
11.
Cudrici C, Boulougoura A, Sheikh V, Freeman A, Sortino O, Katz J, et al.
Clin Immunol
. 2021 Jan;
224:108664.
PMID: 33422677
Objective: Characterize autoantibodies and autoimmune diseases in a prospective cohort of patients with Idiopathic CD4 Lymphocytopenia (ICL) a rare immunodeficiency characterized by an absolute CD4 T count of <300 cells/μl...
12.
Jha S, Ivovic A, Kang H, Meylan F, Hanson E, Rimland C, et al.
J Invest Dermatol
. 2020 Aug;
141(3):688-692.e11.
PMID: 32791068
No abstract available.
13.
Jing C, Castro-Dopico T, Richoz N, Tuong Z, Ferdinand J, Lok L, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(26):15160-15171.
PMID: 32541026
IgG antibodies cause inflammation and organ damage in autoimmune diseases such as systemic lupus erythematosus (SLE). We investigated the metabolic profile of macrophages isolated from inflamed tissues in immune complex...
14.
Song Y, Choi I, Meylan F, Demoruelle M, Farley T, Richard A, et al.
Arthritis Res Ther
. 2020 May;
22(1):106.
PMID: 32381123
Background: The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in...
15.
Kang H, Jha S, Ivovic A, Fratzl-Zelman N, Deng Z, Mitra A, et al.
J Exp Med
. 2020 Apr;
217(5).
PMID: 32232430
Melorheostosis is a rare sclerosing dysostosis characterized by asymmetric exuberant bone formation. Recently, we reported that somatic mosaicism for MAP2K1-activating mutations causes radiographical "dripping candle wax" melorheostosis. We now report...
16.
Jha S, Cowen E, Lehky T, Alter K, Flynn L, Reynolds J, et al.
JBMR Plus
. 2019 Sep;
3(8):e10214.
PMID: 31485554
Melorheostosis is a rare dysostosis involving cortical bone overgrowth that affects the appendicular skeleton. Patients present with pain, deformities, contractures, range of motion limitation(s), and limb swelling. It has been...
17.
Rahman S, Sagar D, Hanna R, Lightfoot Y, Mistry P, Smith C, et al.
Ann Rheum Dis
. 2019 May;
78(7):957-966.
PMID: 31040119
Objectives: The presence of proinflammatory low-density granulocytes (LDG) has been demonstrated in autoimmune and infectious diseases. Recently, regulatory neutrophilic polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) were identified in systemic lupus erythematosus...
18.
Donlin L, Park S, Giannopoulou E, Ivovic A, Park-Min K, Siegel R, et al.
Nat Rev Rheumatol
. 2019 Apr;
15(6):327-339.
PMID: 31000790
Rheumatic diseases have complex aetiologies that are not fully understood, which makes the study of pathogenic mechanisms in these diseases a challenge for researchers. Next-generation sequencing (NGS) and related omics...
19.
Geiger S, Curtis A, ONeill L, Siegel R
Immunology
. 2019 Feb;
157(2):122-136.
PMID: 30773630
Innate immune responses vary in a circadian manner, and more recent investigations aim to understand the underlying molecular mechanisms. Cytokine production varies significantly over the course of a day depending...
20.
Yamamoto T, Lee P, Vodnala S, Gurusamy D, Kishton R, Yu Z, et al.
J Clin Invest
. 2019 Jan;
129(4):1551-1565.
PMID: 30694219
Across clinical trials, T cell expansion and persistence following adoptive cell transfer (ACT) have correlated with superior patient outcomes. Herein, we undertook a pan-cancer analysis to identify actionable ligand-receptor pairs...