Richard M Siegel
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Explore the profile of Richard M Siegel including associated specialties, affiliations and a list of published articles.
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109
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5227
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Recent Articles
1.
Junt T, Calzascia T, Traggiai E, da Costa A, Gergely P, Schett G, et al.
Nat Rev Immunol
. 2025 Mar;
PMID: 40044810
Personalized cell therapies for autoimmune diseases - such as autologous haematopoietic stem cell transplantation and chimeric antigen receptor-expressing T cells - have the potential to achieve sustained remission in patients...
2.
Millar N, McInnes I, Kolbinger F, Raulf F, Akbar M, Li Y, et al.
RMD Open
. 2025 Feb;
11(1).
PMID: 39988349
Objectives: Tendinopathy is a frequent clinical problem and represents an extraordinary health economic and socioeconomic burden with high unmet medical needs. Recent clinical evidence suggests blockade of interleukin 17A (IL-17A)...
3.
Dorner T, Kaul M, Szanto A, Tseng J, Papas A, Pylvaenaeinen I, et al.
Ann Rheum Dis
. 2023 Nov;
83(3):360-371.
PMID: 37932009
Objectives: To evaluate the safety and efficacy of remibrutinib in patients with moderate-to-severe Sjögren's syndrome (SjS) in a phase 2 randomised, double-blind trial (NCT04035668; LOUiSSE (LOU064 in Sjögren's Syndrome) study)....
4.
Cardner M, Tuckwell D, Kostikova A, Forrer P, Siegel R, Marti A, et al.
RMD Open
. 2023 Jun;
9(2).
PMID: 37321668
Objectives: Despite several effective targeted therapies, biomarkers that predict whether a patient with psoriatic arthritis (PsA) will respond to a particular treatment are currently lacking. Methods: We analysed proteomics data...
5.
Aschenbrenner D, Siegel R
Cell Rep Med
. 2023 Mar;
4(3):100983.
PMID: 36948149
Lilja et al. explore single-cell transcriptomes across multiple organs of mice with collagen-induced arthritis. They apply network analysis to prioritize functional pathways that support or suppress inflammation and integrate findings...
6.
Richoz N, Tuong Z, Loudon K, Patino-Martinez E, Ferdinand J, Portet A, et al.
JCI Insight
. 2022 Nov;
7(21).
PMID: 36345939
Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment options. Kidney macrophages are critical tissue sentinels that...
7.
Frazzette N, Cruz A, Wu X, Hammer J, Lippincott-Schwartz J, Siegel R, et al.
Cells
. 2022 Jun;
11(12).
PMID: 35741037
Signaling through the TNF-family receptor Fas/CD95 can trigger apoptosis or non-apoptotic cellular responses and is essential for protection from autoimmunity. Receptor clustering has been observed following interaction with Fas ligand...
8.
Lee Y, Wessel A, Xu J, Reinke J, Lee E, Kim S, et al.
J Clin Invest
. 2022 Mar;
132(6).
PMID: 35289316
Host defense and inflammation are regulated by the NF-κB essential modulator (NEMO), a scaffolding protein with a broad immune cell and tissue expression profile. Hypomorphic mutations in inhibitor of NF-κB...
9.
Willemsen J, Neuhoff M, Hoyler T, Noir E, Tessier C, Sarret S, et al.
Cell Rep
. 2021 Nov;
37(6):109977.
PMID: 34758308
Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which affected tissues show an interferon-stimulated gene signature....
10.
Geiger S, Traba J, Richoz N, Farley T, Brooks S, Petermann F, et al.
Nat Commun
. 2021 May;
12(1):2745.
PMID: 33980856
In mice, time of day strongly influences lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here we show that...