Richard M Locksley
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Explore the profile of Richard M Locksley including associated specialties, affiliations and a list of published articles.
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19240
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Recent Articles
1.
Liao C, Ji M, Wang Z, Drucker D, Liang H, Locksley R
bioRxiv
. 2024 Oct;
PMID: 39463951
One-sentence Summary: Intestinal telocyte TSLP relays signals from enteroendocrine cells to ILC2s to amplify the tuft cell circuit in response to feeding.
2.
Jung H, Kim D, Diaz R, White J, Rucknagel S, Mosby L, et al.
Sci Immunol
. 2024 Oct;
9(100):eadl2986.
PMID: 39423283
Environmental exposures increase the risk for severe lung disease, but specific drivers of persistent epithelial injury and immune dysfunction remain unclear. Here, we identify a feedback circuit triggered by chitin,...
3.
Schuijs M, Gomez C, Bick F, Van Moorleghem J, Vanheerswynghels M, van Loo G, et al.
J Exp Med
. 2024 Sep;
221(12).
PMID: 39297875
Asthma is characterized by lung eosinophilia, remodeling, and mucus plugging, controlled by adaptive Th2 effector cells secreting IL-4, IL-5, and IL-13. Inhaled house dust mite (HDM) causes the release of...
4.
Diaz R, Ecker A, Correy G, Asthana P, Young I, Faust B, et al.
Elife
. 2024 Jun;
12.
PMID: 38884443
Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of...
5.
Zwick R, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis C, et al.
Nat Cell Biol
. 2024 Feb;
26(2):250-262.
PMID: 38321203
A key aspect of nutrient absorption is the exquisite division of labour across the length of the small intestine, with individual nutrients taken up at different proximal:distal positions. For millennia,...
6.
OKeefe R, Carli A, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, et al.
Nat Commun
. 2023 Oct;
14(1):6872.
PMID: 37898600
Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties of the crosstalk between intestinal tuft cells and type...
7.
Zwick R, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis C, et al.
bioRxiv
. 2023 Oct;
PMID: 37790430
A key aspect of nutrient absorption is the exquisite division of labor across the length of the small intestine, with individual classes of micronutrients taken up at different positions. For...
8.
Shaikh N, Waterholter A, Gnirck A, Becker M, Adamiak V, Henneken L, et al.
J Exp Med
. 2023 Sep;
220(12).
PMID: 37773047
Adaptation of immune cells to tissue-specific microenvironments is a crucial process in homeostasis and inflammation. Here, we show that murine effector type 2 innate lymphoid cells (ILC2s) from various organs...
9.
10.
Diaz R, Ecker A, Correy G, Asthana P, Young I, Faust B, et al.
bioRxiv
. 2023 Jul;
PMID: 37398339
Chitin is an abundant biopolymer and pathogen-associated molecular pattern that stimulates a host innate immune response. Mammals express chitin-binding and chitin-degrading proteins to remove chitin from the body. One of...