Richard M Locksley
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Explore the profile of Richard M Locksley including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Sbierski-Kind J, Cautivo K, Wagner J, Dahlgren M, Nilsson J, Krasilnikov M, et al.
bioRxiv
. 2023 May;
PMID: 37163060
Group 2 innate lymphoid cells (ILC2s) cooperate with adaptive Th2 cells as key organizers of tissue type 2 immune responses, while a spectrum of innate and adaptive lymphocytes coordinate early...
12.
Molofsky A, Locksley R
Immunity
. 2023 Apr;
56(4):704-722.
PMID: 37044061
Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by innate lymphoid cells, group 2, and their adaptive counterparts, CD4 helper type 2 cells, and elaborated...
13.
Kotas M, OLeary C, Locksley R
Annu Rev Pathol
. 2022 Nov;
18:311-335.
PMID: 36351364
Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and luminal exposures but converge on a shared transcriptional program, including expression of taste transduction signaling pathways....
14.
Ricardo-Gonzalez R, Kotas M, OLeary C, Singh K, Damsky W, Liao C, et al.
Immunity
. 2022 Aug;
55(10):1891-1908.e12.
PMID: 36044899
Demodex mites are commensal parasites of hair follicles (HFs). Normally asymptomatic, inflammatory outgrowth of mites can accompany malnutrition, immune dysfunction, and aging, but mechanisms restricting Demodex outgrowth are not defined....
15.
Kotas M, Moore C, Gurrola 2nd J, Pletcher S, Goldberg A, Alvarez R, et al.
JCI Insight
. 2022 May;
7(13).
PMID: 35608904
Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are largely attributed to the effects of IL-13 on common...
16.
OLeary C, Sbierski-Kind J, Kotas M, Wagner J, Liang H, Schroeder A, et al.
Sci Immunol
. 2022 Mar;
7(69):eabj1080.
PMID: 35245089
Inflammation and dysfunction of the extrahepatic biliary tree are common causes of human pathology, including gallstones and cholangiocarcinoma. Despite this, we know little about the local regulation of biliary inflammation....
17.
Ricardo-Gonzalez R, Molofsky A, Locksley R
Curr Opin Immunol
. 2022 Feb;
75:102168.
PMID: 35176675
Over the last decade, we have come to appreciate group 2 innate lymphoid cells (ILC2s) as important players in host and tissue immunity. New studies of ILC2s and their precursors...
18.
Cautivo K, Matatia P, Lizama C, Mroz N, Dahlgren M, Yu X, et al.
Immunity
. 2022 Feb;
55(2):254-271.e7.
PMID: 35139352
Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial- and microbial-rich barriers. However, ILC2s and Th2 cells...
19.
Castellanos C, Ren X, Gonzalez S, Li H, Schroeder A, Liang H, et al.
Sci Immunol
. 2021 Oct;
6(64):eabh0707.
PMID: 34652961
Type 2 T helper (T2) cells are protective against parasitic worm infections but also aggravate allergic inflammation. Although the role of dendritic cells (DCs) in T2 cell differentiation is well...
20.
Gschwend J, Sherman S, Ridder F, Feng X, Liang H, Locksley R, et al.
J Exp Med
. 2021 Aug;
218(10).
PMID: 34431978
Programs defining tissue-resident macrophage identity depend on local environmental cues. For alveolar macrophages (AMs), these signals are provided by immune and nonimmune cells and include GM-CSF (CSF2). However, evidence to...