Richard M Beteck
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Explore the profile of Richard M Beteck including associated specialties, affiliations and a list of published articles.
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43
Citations
166
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Recent Articles
1.
Agarwal D, Beteck R, Mabille D, Caljon G, Legoabe L
Naunyn Schmiedebergs Arch Pharmacol
. 2024 Oct;
PMID: 39432069
A series of novel pyrazolyl amide-chalcones conjugates was synthesized in five steps and evaluated against a range of medically important kinetoplastid parasites including Trypanosoma cruzi, Trypanosoma brucei brucei, Trypanosoma brucei...
2.
Jooste J, Legoabe L, Ilbeigi K, Caljon G, Beteck R
Arch Pharm (Weinheim)
. 2024 Jul;
357(10):e2400430.
PMID: 38982314
Geraniol, a primary component of several essential oils, has been associated with broad-spectrum antiprotozoal activities, although moderate to weak. This study primarily concentrated on the synthesis of hydrazinated geraniol derivatives...
3.
Hartman C, Dube P, Legoabe L, Van Pelt N, Matheeussen A, Caljon G, et al.
Arch Pharm (Weinheim)
. 2024 Feb;
357(6):e2300319.
PMID: 38396284
Several quinoline derivatives incorporating arylnitro and aminochalcone moieties were synthesized and evaluated in vitro against a broad panel of trypanosomatid protozoan parasites responsible for sleeping sickness (Trypanosoma brucei rhodesiense), nagana...
4.
Chirwa K, Francisco K, Dube P, Park H, Legoabe L, Teixeira T, et al.
ChemMedChem
. 2024 Feb;
19(9):e202300667.
PMID: 38326914
Nagana and Human African Trypanosomiasis (HAT), caused by (sub)species of Trypanosoma, are diseases that impede human and animal health, and economic growth in Africa. The few drugs available have drawbacks...
5.
Agarwal D, Beteck R, Ilbeigi K, Caljon G, Legoabe L
Chem Biol Drug Des
. 2023 Nov;
103(1):e14400.
PMID: 37994272
A library of imidazo[1,2-a]pyridine-appended chalcones were synthesized and characterized using H NMR, C NMR and HRMS. The synthesized analogues were screened for their antikinetoplastid activity against Trypanosoma cruzi, Trypanosoma brucei...
6.
Setshedi K, Beteck R, Jesumoroti O, Ilbeigi K, Mabille D, Caljon G, et al.
Chem Biol Drug Des
. 2023 Jun;
102(4):763-772.
PMID: 37353860
Trypanosomes and Leishmania are parasitic protozoans that affect millions of people globally. Herein we report the synthesis of 2-aroyl quinazolinones and their antiprotozoal efficacy against Trypanosoma brucei, Trypanosoma brucei rhodesiense,...
7.
Agarwal D, Sakhuja R, Beteck R, Legoabe L
Steroids
. 2023 Jun;
197:109258.
PMID: 37330161
Steroids are biomolecules that play pivotal roles in various physiological and drug discovery processes. Abundant research has been fuelled towards steroid-heterocycles conjugates over the last few decades as potential therapeutic...
8.
Dube P, Legoabe L, Jordaan A, Sigauke L, Warner D, Beteck R
Eur J Med Chem
. 2023 Jun;
258:115539.
PMID: 37321107
Mycobacterium tuberculosis (Mtb) has an impermeable cell wall which gives it an inherent ability to resist many antibiotics. DprE1, an essential enzyme in Mtb cell wall synthesis, has been validated...
9.
Dube P, Angula K, Legoabe L, Jordaan A, Boitz Zarella J, Warner D, et al.
ACS Omega
. 2023 May;
8(19):17086-17102.
PMID: 37214682
Herein, we describe 39 novel quinolone compounds bearing a hydrophilic amine chain and varied substituted benzyloxy units. These compounds demonstrate broad-spectrum activities against acid-fast bacterium, Gram-positive and -negative bacteria, fungi,...
10.
Ramseier J, Imhof D, Hanggeli K, Anghel N, Boubaker G, Beteck R, et al.
Pathogens
. 2023 Mar;
12(3).
PMID: 36986369
The effects of decoquinate (DCQ) and three -quinoline-carbamate-derivatives were investigated using human foreskin fibroblasts (HFF) infected with tachyzoites. These compounds exhibited half-maximal proliferation inhibition (ICs) from 1.7 (RMB060) to 60...