Richard L Moss
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Explore the profile of Richard L Moss including associated specialties, affiliations and a list of published articles.
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88
Citations
3650
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Recent Articles
1.
Mertens J, de Lange W, Farrell E, Harbaugh E, Gauchan A, Fitzsimons D, et al.
J Mol Cell Cardiol
. 2024 Jul;
195:14-23.
PMID: 39059462
Missense mutations in cardiac myosin binding protein C (cMyBP-C) are known to cause hypertrophic cardiomyopathy (HCM). The W792R mutation in the C6 domain of cMyBP-C causes severe, early onset HCM...
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de Lange W, Farrell E, Hernandez J, Stempien A, Kreitzer C, Jacobs D, et al.
J Gen Physiol
. 2023 Mar;
155(4).
PMID: 36893011
Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes of hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM, while homozygous carriers present with early onset HCM...
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Hanft L, Fitzsimons D, Hacker T, Moss R, McDonald K
J Gen Physiol
. 2021 Mar;
153(7).
PMID: 33646280
The Frank-Starling relationship establishes that elevated end-diastolic volume progressively increases ventricular pressure and stroke volume in healthy hearts. The relationship is modulated by a number of physiological inputs and is...
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Giles J, Fitzsimons D, Patel J, Knudtsen C, Neuville A, Moss R
J Gen Physiol
. 2021 Feb;
153(3).
PMID: 33566084
In myocardium, phosphorylation of cardiac myosin-binding protein-C (cMyBP-C) is thought to modulate the cooperative activation of the thin filament by binding to myosin and/or actin, thereby regulating the probability of...
7.
Tucholski T, Cai W, Gregorich Z, Bayne E, Mitchell S, Mcilwain S, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(40):24691-24700.
PMID: 32968017
Hypertrophic cardiomyopathy (HCM) is the most common heritable heart disease. Although the genetic cause of HCM has been linked to mutations in genes encoding sarcomeric proteins, the ability to predict...
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