Julian E Stelzer
Overview
Explore the profile of Julian E Stelzer including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
52
Citations
1366
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Dominic K, Schmidt A, Granzier H, Campbell K, Stelzer J
Front Physiol
. 2024 Dec;
15:1512550.
PMID: 39726859
Heart failure with preserved ejection fraction (HFpEF) is a major public health challenge, affecting millions worldwide and placing a significant burden on healthcare systems due to high hospitalization rates and...
2.
Choi J, Wood P, Holmes J, Dominic K, Dos Remedios C, Campbell K, et al.
Am J Physiol Heart Circ Physiol
. 2024 Oct;
328(1):H161-H173.
PMID: 39453428
The second-generation myosin activator danicamtiv (DN) has shown improved function compared with the first-generation myosin activator omecamtiv mecarbil (OM) in nonfailing myocardium by enhancing cardiac force generation but attenuating slowed...
3.
Doh C, Schmidt A, Chinthalapudi K, Stelzer J
Front Physiol
. 2024 Mar;
15:1370539.
PMID: 38487262
Myosin binding protein C (MyBPC) is a multi-domain protein with each region having a distinct functional role in muscle contraction. The central domains of MyBPC have often been overlooked due...
4.
Ananthamohan K, Stelzer J, Sadayappan S
J Cardiovasc Aging
. 2024 Feb;
4(1.
PMID: 38406555
Hypertrophic cardiomyopathy (HCM) is characterized by abnormal thickening of the myocardium, leading to arrhythmias, heart failure, and elevated risk of sudden cardiac death, particularly among the young. This inherited disease...
5.
Choi J, Holmes J, Campbell K, Stelzer J
J Am Heart Assoc
. 2023 Oct;
12(20):e030682.
PMID: 37804193
Background Omecamtiv mecarbil (OM) and danicamtiv both increase myocardial force output by selectively activating myosin within the cardiac sarcomere. Enhanced force generation is presumably due to an increase in the...
6.
Doh C, Kampourakis T, Campbell K, Stelzer J
Front Cardiovasc Med
. 2023 Aug;
10:1238515.
PMID: 37600050
With the advent of next-generation whole genome sequencing, many variants of uncertain significance (VUS) have been identified in individuals suffering from inheritable hypertrophic cardiomyopathy (HCM). Unfortunately, this classification of a...
7.
Holmes J, Lemieux M, Stelzer J
Am J Physiol Heart Circ Physiol
. 2023 Jul;
325(3):H449-H467.
PMID: 37417875
Detailed assessments of whole heart mechanics are crucial for understanding the consequences of sarcomere perturbations that lead to cardiomyopathy in mice. Echocardiography offers an accessible and cost-effective method of obtaining...
8.
Dominic K, Choi J, Holmes J, Singh M, Majcher M, Stelzer J
J Gen Physiol
. 2023 Apr;
155(6).
PMID: 37067542
Cardiac myosin binding protein C (cMyBPC) is an 11-domain sarcomeric protein (C0-C10) integral to cardiac muscle regulation. In vitro studies have demonstrated potential functional roles for regions beyond the N-terminus....
9.
Doh C, Dominic K, Swanberg C, Bharambe N, Willard B, Li L, et al.
ACS Omega
. 2022 May;
7(16):14189-14202.
PMID: 35573219
Cardiac myosin binding protein C (cMyBPC) is a critical multidomain protein that modulates myosin cross bridge behavior and cardiac contractility. cMyBPC is principally regulated by phosphorylation of the residues within...
10.
Doh C, Bharambe N, Holmes J, Dominic K, Swanberg C, Mamidi R, et al.
J Struct Biol
. 2022 Apr;
214(2):107856.
PMID: 35427781
Introduction: The central C4 and C5 domains (C4C5) of cardiac myosin binding protein C (cMyBPC) contain a flexible interdomain linker and a cardiac-isoform specific loop. However, their importance in the...