Richard L Kitchens
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Explore the profile of Richard L Kitchens including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
497
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Recent Articles
1.
Shao B, Kitchens R, Munford R, Rogers T, Rockey D, Varley A
Hepatology
. 2011 Jun;
54(3):1051-62.
PMID: 21674560
Unlabelled: Transient hepatomegaly often accompanies acute bacterial infections. Reversible, dose-dependent hepatomegaly also occurs when animals are given intravenous infusions of bacterial lipopolysaccharide (LPS). We found that recovery from LPS-induced hepatomegaly...
2.
Thompson P, Gauthier K, Varley A, Kitchens R
J Lipid Res
. 2010 May;
51(9):2672-85.
PMID: 20472936
Macrophages play important roles in both lipid metabolism and innate immunity. We show here that macrophage ATP-binding cassette transporter A1 (ABCA1), a transporter known for its ability to promote apolipoprotein-dependent...
3.
Thompson P, Berbee J, Rensen P, Kitchens R
Innate Immun
. 2008 Nov;
14(6):365-74.
PMID: 19039060
Lipopolysaccharide (LPS) binding protein (LBP) plays an important role in regulating leukocyte responses to LPS. Remarkably, it may either augment these responses at low LBP concentrations or inhibit them at...
4.
Li L, Thompson P, Kitchens R
J Lipid Res
. 2008 May;
49(8):1782-93.
PMID: 18497424
Apolipoprotein E (apoE) plays important roles in lipid homeostasis, anti-inflammation, and host defense. Since tissue apoE mRNA levels have been reported to decrease during inflammatory responses, we were surprised to...
5.
Thompson P, Kitchens R
J Immunol
. 2006 Sep;
177(7):4880-7.
PMID: 16982930
High-density lipoprotein (HDL) is an abundant plasma lipoprotein that is generally thought to be anti-inflammatory in both health and infectious disease. It binds and neutralizes the bioactivity of the potent...
6.
Berbee J, van der Hoogt C, Kleemann R, Schippers E, Kitchens R, van Dissel J, et al.
FASEB J
. 2006 Aug;
20(12):2162-4.
PMID: 16935938
Gram-negative sepsis is a major death cause in intensive care units. Accumulating evidence indicates the protective role of plasma lipoproteins such as high-density lipoprotein (HDL) in sepsis. It has recently...
7.
Seetharam D, Mineo C, Gormley A, Gibson L, Vongpatanasin W, Chambliss K, et al.
Circ Res
. 2005 Dec;
98(1):63-72.
PMID: 16339487
Vascular disease risk is inversely related to circulating levels of high-density lipoprotein (HDL) cholesterol. However, the mechanisms by which HDL provides vascular protection are unclear. The disruption of endothelial monolayer...
8.
Kitchens R, Thompson P
J Endotoxin Res
. 2005 Sep;
11(4):225-9.
PMID: 16176659
LPS binding protein (LBP) and CD14 play key roles in promoting innate immunity to Gram-negative bacteria by transferring LPS to the signaling receptor complex, MD-2/Toll-like receptor 4 (TLR4). LBP and...
9.
Kitchens R, Thompson P, Munford R, OKeefe G
J Lipid Res
. 2003 Aug;
44(12):2339-48.
PMID: 12923224
Circulating lipoproteins are thought to play an important role in the detoxification of lipopolysaccharide (LPS) by binding the bioactive lipid A portion of LPS to the lipoprotein surface. It has...
10.
Lu M, Zhang M, Kitchens R, Fosmire S, Takashima A, Munford R
J Exp Med
. 2003 Jun;
197(12):1745-54.
PMID: 12810692
We describe here a previously unrecognized property of dendritic cells (DCs), the ability to deacylate the lipid A moiety of gram-negative bacterial LPSs. Both immature DCs of the XS52 cell...