Richard Kriwacki
Overview
Explore the profile of Richard Kriwacki including associated specialties, affiliations and a list of published articles.
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26
Citations
2737
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Recent Articles
11.
Pinto E, Maxwell K, Halalsheh H, Phillips A, Powers J, MacFarland S, et al.
Mol Cancer Res
. 2021 Oct;
20(2):207-216.
PMID: 34675114
Germline splicing variants are uncommon, and their clinical relevance is unknown. However, splice-altering variants at exon 4-intron 4 junctions are relatively enriched in pediatric adrenocortical tumors (ACT). Nevertheless, family histories...
12.
Gibbs E, Perrone B, Hassan A, Kummerle R, Kriwacki R
J Magn Reson
. 2019 Nov;
310:106646.
PMID: 31751897
Nucleophosmin (NPM1) is an abundant nucleolar protein that aids in the maturation of pre-ribosomal particles and participates in oncogenic stress responses through its interaction with the Alternative Reading Frame tumor...
13.
Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
Tsytlonok M, Sanabria H, Wang Y, Felekyan S, Hemmen K, Phillips A, et al.
Nat Commun
. 2019 Apr;
10(1):1676.
PMID: 30976006
p27 is an intrinsically disordered protein (IDP) that inhibits cyclin-dependent kinase (Cdk)/cyclin complexes (e.g., Cdk2/cyclin A), causing cell cycle arrest. Cell division progresses when stably Cdk2/cyclin A-bound p27 is phosphorylated...
14.
Teitz T, Fang J, Goktug A, Bonga J, Diao S, Hazlitt R, et al.
J Exp Med
. 2018 Mar;
215(4):1187-1203.
PMID: 29514916
Hearing loss caused by aging, noise, cisplatin toxicity, or other insults affects 360 million people worldwide, but there are no Food and Drug Administration-approved drugs to prevent or treat it....
15.
Pitre A, Ge Y, Lin W, Wang Y, Fukuda Y, Temirov J, et al.
Nat Commun
. 2017 Nov;
8(1):1547.
PMID: 29146910
The overall survival of patients with acute myeloid leukemia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal for this disease. Here we show that...
16.
Northcott P, Buchhalter I, Morrissy A, Hovestadt V, Weischenfeldt J, Ehrenberger T, et al.
Nature
. 2017 Jul;
547(7663):311-317.
PMID: 28726821
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight the need for molecularly targeted treatments with reduced toxicity. Previous studies...
17.
Andersson A, Ma J, Wang J, Chen X, Gedman A, Dang J, et al.
Nat Genet
. 2015 Mar;
47(4):330-7.
PMID: 25730765
Infant acute lymphoblastic leukemia (ALL) with MLL rearrangements (MLL-R) represents a distinct leukemia with a poor prognosis. To define its mutational landscape, we performed whole-genome, exome, RNA and targeted DNA...
18.
Wu G, Diaz A, Paugh B, Rankin S, Ju B, Li Y, et al.
Nat Genet
. 2014 Apr;
46(5):444-450.
PMID: 24705251
Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs)...
19.
Jakob U, Kriwacki R, Uversky V
Chem Rev
. 2014 Feb;
114(13):6779-805.
PMID: 24502763
No abstract available.
20.
Mann B, Thornton J, Heath R, Wade K, Tweten R, Gao G, et al.
J Infect Dis
. 2013 Sep;
209(7):1116-25.
PMID: 24041791
Background: Pneumococcus, meningococcus, and Haemophilus influenzae cause a similar spectrum of infections in the ear, lung, blood, and brain. They share cross-reactive antigens that bind to the laminin receptor of...