Richard Killick
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Explore the profile of Richard Killick including associated specialties, affiliations and a list of published articles.
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52
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2255
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Recent Articles
1.
Elliott C, Jackson J, Findlay J, Williams G, Ghosh A, Ribe E, et al.
Cell Signal
. 2025 Mar;
131:111716.
PMID: 40057150
Synapse loss driven by amyloid-β (Aβ) is an early event in Alzheimer's disease (AD). Although the mechanism by which Aβ drives synapse loss remain poorly understood data indicate that a...
2.
Piers T, Fang K, Namboori S, Liddle C, Rogers S, Bhinge A, et al.
Development
. 2024 Nov;
151(23).
PMID: 39576204
Synaptogenesis involves the transformation of dendritic filopodial contacts into stable connections with the exact apposition of synaptic components. Signalling triggered by Wnt/β-catenin and calcium has been postulated to aid this...
3.
Lemche E, Killick R, Mitchell J, Caton P, Choudhary P, Howard J
Neurobiol Dis
. 2024 Apr;
196():106485.
PMID: 38643861
Research evidence indicating common metabolic mechanisms through which type 2 diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has accumulated over recent decades. The aim of this systematic...
4.
Collu R, Yin Z, Giunti E, Daley S, Chen M, Morin P, et al.
Front Aging Neurosci
. 2024 Mar;
16:1323563.
PMID: 38440100
Introduction: The goal of this study is to explore the pharmacological potential of the amyloid-reducing vasodilator fasudil, a selective Ras homolog (Rho)-associated kinases (ROCK) inhibitor, in the P301S tau transgenic...
5.
Giunti E, Collu R, Daley S, Querfurth H, Morin P, Killick R, et al.
J Alzheimers Dis
. 2023 Nov;
96(4):1695-1709.
PMID: 38007655
Background: Alzheimer's disease (AD) is the most predominant form of dementia. Rho-associated coiled coil kinase (ROCK) inhibitor, fasudil, is one of the candidate drugs against the AD progression. Objective: We...
6.
Khan A, Killick R, Wirth D, Hoogland D, Hristova K, Ulmschneider J, et al.
Alzheimers Dement (N Y)
. 2023 Nov;
9(4):e12428.
PMID: 37954165
Introduction: Reducing brain levels of both soluble and insoluble forms of amyloid beta (Aβ) remains the primary goal of most therapies that target Alzheimer's disease (AD). However, no treatment has...
7.
Killick R, Elliott C, Ribe E, Broadstock M, Ballard C, Aarsland D, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37446396
The pan Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor fasudil acts as a vasodilator and has been used as a medication for post-cerebral stroke for the past 29 years in Japan...
8.
Boorman E, Killick R, Aarsland D, Zunszain P, Mann G
Free Radic Biol Med
. 2022 Oct;
193(Pt 1):437-446.
PMID: 36272667
The birth of new neurons from neural stem cells (NSC)s during developmental and adult neurogenesis arises from a myriad of highly complex signalling cascades. Emerging as one of these is...
9.
Kim E, Di Censo D, Baraldo M, Simmons C, Rosa I, Randall K, et al.
Sci Rep
. 2021 Jun;
11(1):12419.
PMID: 34127752
Amyloid plaques are a hallmark of Alzheimer's disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and...
10.
Killick R, Ballard C, Doherty P, Williams G
Virus Res
. 2020 Sep;
290:198176.
PMID: 32987033
We have utilised the transcriptional response of lung epithelial cells following infection by the original Severe Acute Respiratory Syndrome coronavirus (SARS) to identify repurposable drugs for COVID-19. Drugs best able...