Richard J Wheeler
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Explore the profile of Richard J Wheeler including associated specialties, affiliations and a list of published articles.
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32
Citations
849
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Recent Articles
1.
Doran M, Niu Q, Zeng J, Beneke T, Smith J, Ren P, et al.
Science
. 2025 Mar;
387(6739):eadr5507.
PMID: 40080577
The movement and pathogenicity of trypanosomatid species, the causative agents of trypanosomiasis and leishmaniasis, are dependent on a flagellum that contains an axoneme of dynein-bound doublet microtubules (DMTs). In this...
2.
Carbajo C, Han X, Savur B, Upadhyaya A, Taha F, Tinti M, et al.
Open Biol
. 2025 Feb;
15(2):240334.
PMID: 39999874
Kinetoplastid parasites cause diseases that threaten human and animal health. To survive transitions between vertebrate hosts and insect vectors, these parasites rely on precise regulation of gene expression to adapt...
3.
Park J, Prokopchuk G, Popchock A, Hao J, Liao T, Yan S, et al.
bioRxiv
. 2025 Jan;
PMID: 39763889
Connections between the mechanical properties of DNA and biological functions have been speculative due to the lack of methods to measure or predict DNA mechanics at scale. Recently, a proxy...
4.
Albuquerque-Wendt A, McCoy C, Neish R, Dobramysl U, Alagoz C, Beneke T, et al.
Nat Commun
. 2025 Jan;
16(1):299.
PMID: 39747086
For the protozoan parasite Leishmania, completion of its life cycle requires sequential adaptation of cellular physiology and nutrient scavenging mechanisms to the different environments of a sand fly alimentary tract...
5.
Carbajo C, Han X, Savur B, Upadhyaya A, Taha F, Tinti M, et al.
bioRxiv
. 2024 Nov;
PMID: 39554005
Kinetoplastid parasites cause diseases that threaten human and animal health. To survive transitions between vertebrate hosts and insect vectors, these parasites rely on precise regulation of gene expression to adapt...
6.
Azevedo L, Sosa E, de Queiroz A, Barral A, Wheeler R, Nicolas M, et al.
Int J Parasitol Drugs Drug Resist
. 2024 Apr;
25:100538.
PMID: 38669848
Leishmaniasis, a vector-borne disease, is caused by the infection of Leishmania spp., obligate intracellular protozoan parasites. Presently, human vaccines are unavailable, and the primary treatment relies heavily on systemic drugs,...
7.
Sozanschi A, Asiki H, Amaral M, de Castro Levatti E, Tempone A, Wheeler R, et al.
JACS Au
. 2024 Mar;
4(2):847-854.
PMID: 38425909
Visceral leishmaniasis and Chagas disease are neglected tropical diseases (NTDs) that severely impact the developing world. With current therapies suffering from poor efficacy and safety profiles as well as emerging...
8.
Ramakrishnan C, Fort C, Marques S, Ferguson D, Gransagne M, Baum J, et al.
J Cell Sci
. 2023 Jun;
136(11).
PMID: 37288670
Flagella are important for eukaryote cell motility, including in sperm, and are vital for life cycle progression of many unicellular eukaryotic pathogens. The '9+2' axoneme in most motile flagella comprises...
9.
Halliday C, Dean S, Sunter J, Wheeler R
Wellcome Open Res
. 2023 May;
8:46.
PMID: 37251657
Genome-wide subcellular protein localisation in through our TrypTag project, has comprehensively dissected the molecular organisation of this important pathogen. Powerful as this resource is has multiple developmental forms and we...
10.
Beneke T, Dobramysl U, Costa Catta-Preta C, Mottram J, Gluenz E, Wheeler R
Wellcome Open Res
. 2023 Mar;
7:294.
PMID: 36874584
We present the genome sequence of MNYC/BZ/62/M379 modified to express Cas9 and T7 RNA-polymerase, revealing high similarity to the reference genome (MHOM/GT2001/U1103). Through RNAseq-based annotation of coding sequences and untranslated...