Keith Gull
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Explore the profile of Keith Gull including associated specialties, affiliations and a list of published articles.
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124
Citations
6630
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Recent Articles
1.
Pyrih J, Hammond M, Alves A, Dean S, Sunter J, Wheeler R, et al.
Cell Rep
. 2023 Sep;
42(9):113083.
PMID: 37669165
We have generated a high-confidence mitochondrial proteome (MitoTag) of the Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a mitochondrial localization had not been described before. We...
2.
Billington K, Halliday C, Madden R, Dyer P, Barker A, Moreira-Leite F, et al.
Nat Microbiol
. 2023 Feb;
8(3):533-547.
PMID: 36804636
Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and plant unicellular parasites. Understanding their complex cell architecture and life cycle is challenging because, as with most...
3.
Lopez-Escobar L, Hanisch B, Halliday C, Ishii M, Akiyoshi B, Dean S, et al.
Nat Microbiol
. 2022 Jul;
7(8):1280-1290.
PMID: 35879525
Variant surface glycoprotein (VSG) coats bloodstream form Trypanosoma brucei parasites, and monoallelic VSG expression underpins the antigenic variation necessary for pathogenicity. One of thousands of VSG genes is transcribed by...
4.
Lai D, Moreira-Leite F, Xu Z, Yang J, Gull K
Proc Natl Acad Sci U S A
. 2021 Feb;
118(8).
PMID: 33597294
Centrioles and basal bodies (CBBs) are found in physically linked pairs, and in mammalian cells intercentriole connections (G1-G2 tether and S-M linker) regulate centriole duplication and function. In trypanosomes BBs...
5.
Wheeler R, Gull K, Sunter J
Annu Rev Microbiol
. 2019 Sep;
73:133-154.
PMID: 31500537
Trypanosomes have complex life cycles within which there are both proliferative and differentiation cell divisions. The coordination of the cell cycle to achieve these different divisions is critical for the...
6.
Abeywickrema M, Vachova H, Farr H, Mohr T, Wheeler R, Lai D, et al.
Mol Microbiol
. 2019 Jul;
112(3):1024-1040.
PMID: 31286583
Differentiation of Trypanosoma brucei, a flagellated protozoan parasite, between life cycle stages typically occurs through an asymmetric cell division process, producing two morphologically distinct daughter cells. Conversely, proliferative cell divisions...
7.
Sunter J, Yanase R, Wang Z, Costa Catta-Preta C, Moreira-Leite F, Myskova J, et al.
Proc Natl Acad Sci U S A
. 2019 Mar;
116(13):6351-6360.
PMID: 30850532
kinetoplastid parasites infect millions of people worldwide and have a distinct cellular architecture depending on location in the host or vector and specific pathogenicity functions. An invagination of the cell...
8.
Dean S, Moreira-Leite F, Gull K
Elife
. 2019 Feb;
8.
PMID: 30810527
Most motile flagella have an axoneme that contains nine outer microtubule doublets and a central pair (CP) of microtubules. The CP coordinates the flagellar beat and defects in CP projections...
9.
Sunter J, Moreira-Leite F, Gull K
Open Biol
. 2018 Nov;
8(11).
PMID: 30463910
Flagella have multiple functions that are associated with different axonemal structures. Motile flagella typically have a 9 + 2 arrangement of microtubules, whereas sensory flagella normally have a 9 +...
10.