Richard I Tapping
Overview
Explore the profile of Richard I Tapping including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
1230
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Recent Articles
1.
Deb P, Singh S, Kalyoussef E, Hess N, Tapping R, Fitzgerald-Bocarsly P
J Immunol
. 2024 Jul;
213(5):577-587.
PMID: 38995177
TLRs are the most thoroughly studied group of pattern-recognition receptors that play a central role in innate immunity. Among them, TLR10 (CD290) remains the only TLR family member without a...
2.
Hess N, Felicelli C, Grage J, Tapping R
J Leukoc Biol
. 2017 Feb;
101(5):1245-1252.
PMID: 28235773
TLRs are important pattern-recognition receptors involved in the activation of innate immune responses against foreign pathogens. TLR10 is the only TLR family member without a known ligand, signaling pathway, or...
3.
Hess N, Jiang S, Li X, Guan Y, Tapping R
J Immunol
. 2016 Dec;
198(2):699-707.
PMID: 27956526
Toll-like receptors play a central role in the initiation of adaptive immune responses with several TLR agonists acting as known B cell mitogens. Despite thousands of publications on TLRs, the...
4.
Tencati M, Tapping R
Infect Immun
. 2016 Aug;
84(10):2904-13.
PMID: 27481241
Yersinia pestis is a Gram-negative bacterium that is the causative agent of bubonic and pneumonic plague. It is commonly acquired by mammals such as rodents and humans via the bite...
5.
Jiang S, Li X, Hess N, Guan Y, Tapping R
J Immunol
. 2016 Mar;
196(9):3834-41.
PMID: 27022193
TLRs are central components of the innate immune system which, upon recognition of bacterial, fungal or viral components, activate intracellular signals that lead to protective inflammatory responses. Among the 10-member...
6.
Mattis D, Chervin A, Ranoa D, Kelley S, Tapping R, Kranz D
Mol Immunol
. 2015 Sep;
68(2 Pt A):203-12.
PMID: 26320630
Bacterial lipopolysaccharide (LPS) activates the innate immune system by forming a complex with myeloid differentiation factor 2 (MD-2) and Toll-like receptor 4 (TLR4), which is present on antigen presenting cells....
7.
Ranoa D, Kelley S, Tapping R
J Biol Chem
. 2013 Feb;
288(14):9729-9741.
PMID: 23430250
Bacterial lipoproteins are the most potent microbial agonists for the Toll-like receptor 2 (TLR2) subfamily, and this pattern recognition event induces cellular activation, leading to host immune responses. Triacylated bacterial...
8.
Kelley S, Lukk T, Nair S, Tapping R
J Immunol
. 2012 Dec;
190(3):1304-11.
PMID: 23264655
Human monocyte differentiation Ag CD14 is a pattern recognition receptor that enhances innate immune responses to infection by sensitizing host cells to bacterial LPS (endotoxin), lipoproteins, lipoteichoic acid, and other...
9.
Hart B, Tapping R
J Immunol
. 2012 Oct;
189(11):5347-55.
PMID: 23105135
We recently identified I602S as a frequent single-nucleotide polymorphism of human TLR1 that greatly inhibits cell surface trafficking, confers hyporesponsiveness to TLR1 agonists, and protects against the mycobacterial diseases leprosy...
10.
Hart B, Tapping R
J Trop Med
. 2012 Apr;
2012:415057.
PMID: 22529866
Genetic association studies of leprosy cohorts across the world have identified numerous polymorphisms which alter susceptibility and outcome to infection with Mycobacterium leprae. As expected, many of the polymorphisms reside...