Richard G Brennan
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Explore the profile of Richard G Brennan including associated specialties, affiliations and a list of published articles.
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92
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3855
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Recent Articles
1.
Washington E, Zhou Y, Hsu A, Petrovich M, Tenor J, Toffaletti D, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(32):e2314087121.
PMID: 39083421
Invasive fungal diseases are a major threat to human health, resulting in more than 1.5 million annual deaths worldwide. The arsenal of antifungal therapeutics remains limited and is in dire...
2.
Gallagher K, Tschowri N, Brennan R, Schumacher M, Buttner M
Curr Opin Microbiol
. 2024 Jul;
80:102516.
PMID: 39059031
Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling...
3.
Gaggioli M, Jones A, Panagi I, Washington E, Loney R, Muench J, et al.
bioRxiv
. 2024 Feb;
PMID: 38405869
Non-typhoidal cause an estimated 1 million cases of gastroenteritis annually in the United States. These serovars use secreted protein effectors to mimic and reprogram host cellular functions. We previously discovered...
4.
Hooks G, Ayala J, Holley C, Dhulipala V, Beggs G, Perfect J, et al.
Nat Commun
. 2024 Feb;
15(1):1153.
PMID: 38326294
Transcriptional regulator MtrR inhibits the expression of the multidrug efflux pump operon mtrCDE in the pathogenic bacterium Neisseria gonorrhoeae. Here, we show that MtrR binds the hormonal steroids progesterone, β-estradiol,...
5.
Hooks G, Ayala J, Beggs G, Perfect J, Schumacher M, Shafer W, et al.
bioRxiv
. 2023 Jul;
PMID: 37398116
Overexpression of the multidrug efflux pump MtrCDE, a critical factor of multidrug-resistance in , the causative agent of gonorrheae, is repressed by the transcriptional regulator, MtrR (multiple transferable resistance repressor)....
6.
Washington E, Zhou Y, Hsu A, Petrovich M, Tenor J, Toffaletti D, et al.
bioRxiv
. 2023 Mar;
PMID: 36993618
Significance Statement: Fungal infections are responsible for over a million deaths worldwide each year. Biosynthesis of a disaccharide, trehalose, is required for multiple pathogenic fungi to transition from the environment...
7.
Schott B, Wang L, Zhu X, Harding A, Ko E, Bourgeois J, et al.
Cell Genom
. 2022 Dec;
2(11).
PMID: 36465279
During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human susceptibility testing (scHi-HOST), a method for rapidly identifying genetic variants that confer resistance and...
8.
Travis B, Peck J, Salinas R, Dopkins B, Lent N, Nguyen V, et al.
Nat Commun
. 2022 Jul;
13(1):3793.
PMID: 35778410
How bacteria sense and respond to nitrogen levels are central questions in microbial physiology. In Gram-positive bacteria, nitrogen homeostasis is controlled by an operon encoding glutamine synthetase (GS), a dodecameric...
9.
Anderson B, Schumacher M, Yang J, Turdiev A, Turdiev H, Schroeder J, et al.
Nucleic Acids Res
. 2021 Dec;
50(2):847-866.
PMID: 34967415
The nucleotide messenger (p)ppGpp allows bacteria to adapt to fluctuating environments by reprogramming the transcriptome. Despite its well-recognized role in gene regulation, (p)ppGpp is only known to directly affect transcription...
10.
Schumacher M, Gallagher K, Holmes N, Chandra G, Henderson M, Kysela D, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(30).
PMID: 34290147
Filamentous actinobacteria of the genus have a complex lifecycle involving the differentiation of reproductive aerial hyphae into spores. We recently showed c-di-GMP controls this transition by arming a unique anti-σ,...