Richard E Mains
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Explore the profile of Richard E Mains including associated specialties, affiliations and a list of published articles.
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118
Citations
2808
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Recent Articles
1.
Trivellin G, Daly A, Hernandez-Ramirez L, Araldi E, Tatsi C, Dale R, et al.
Front Endocrinol (Lausanne)
. 2023 Jun;
14:1166076.
PMID: 37388215
Introduction: Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical...
2.
Trivellin G, Daly A, Hernandez-Ramirez L, Araldi E, Tatsi C, Dale R, et al.
medRxiv
. 2023 Jan;
PMID: 36711613
Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects...
3.
Structure of the Sec14 domain of Kalirin reveals a distinct class of lipid-binding module in RhoGEFs
Li Y, Pustovalova Y, Doukov T, Hoch J, Mains R, Eipper B, et al.
Nat Commun
. 2023 Jan;
14(1):96.
PMID: 36609407
Gated entry of lipophilic ligands into the enclosed hydrophobic pocket in stand-alone Sec14 domain proteins often links lipid metabolism to membrane trafficking. Similar domains occur in multidomain mammalian proteins that...
4.
Luxmi R, Mains R, Eipper B, King S
Proc Natl Acad Sci U S A
. 2022 Jul;
119(31):e2206098119.
PMID: 35878031
Cilia are sensory and secretory organelles that both receive information from the environment and transmit signals. Cilia-derived vesicles (ectosomes), formed by outward budding of the ciliary membrane, carry enzymes and...
5.
Merkler D, Hawley A, Eipper B, Mains R
Br J Pharmacol
. 2022 Feb;
179(13):3306-3324.
PMID: 35124797
Peptides play a key role in controlling many physiological and neurobiological pathways. Many bioactive peptides require a C-terminal α-amide for full activity. The bifunctional enzyme catalysing α-amidation, peptidylglycine α-amidating monooxygenase...
6.
Daniel Bartels E, Gotze J, Mains R, Eipper B
J Clin Cardiol
. 2022 Jan;
2(4):75-80.
PMID: 35098246
The electron-dense spherical granules found in the perinuclear region of atrial myocytes store and release both proatrial and probrain natriuretic peptides (proANP and proBNP, respectively). Mature ANP and BNP produce...
7.
Back N, Mains R, Eipper B
FEBS J
. 2021 Jun;
289(15):4470-4496.
PMID: 34089560
Our understanding of the ways in which peptides are used for communication in the nervous and endocrine systems began with the identification of oxytocin, vasopressin, and insulin, each of which...
8.
Rao V, Eipper B, Mains R
J Cell Physiol
. 2021 Jun;
236(11):7745-7758.
PMID: 34061983
The biosynthesis of many of the peptides involved in homeostatic control requires peptidylglycine α-amidating monooxygenase (PAM), an ancient, highly conserved copper- and ascorbate-dependent enzyme. Using the production of amidated chromogranin...
9.
Yasko J, Mains R
Trends Cell Mol Biol
. 2021 Feb;
13:67-84.
PMID: 33564218
Traumatic spinal cord injury (SCI) has devastating implications for patients, including a high prevalence of chronic pain. Despite advancements in our understanding of the mechanisms involved post-SCI, there are no...
10.
Powers K, Ma X, Eipper B, Mains R
Genes Brain Behav
. 2020 Sep;
20(2):e12699.
PMID: 32902163
Neuropeptides and peptide hormones play a crucial role in integrating the many factors that affect physiologic and cognitive processes. The potency of many of these peptides requires an amidated amino...