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Richard Clothier

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Recent Articles
1.
Barker-Treasure C, Coll K, Belot N, Longmore C, Bygrave K, Avey S, et al.
Altern Lab Anim . 2015 Aug; 43(3):199-203. PMID: 26256397
Current approaches to predicting adverse effects in humans from acute toxic exposure to cosmetic ingredients still heavily necessitate the use of animals under EU legislation, particularly in the context of...
2.
Combes R, Balls M, Bansil L, Barratt M, Bell D, Botham P, et al.
Altern Lab Anim . 2013 Apr; 32 Suppl 1B:635-42. PMID: 23581152
FRAME (the Fund for the Replacement of Animals in Medical Experiments; http://www. frame.org.uk) is a scientific charity, which has, for over 30 years, been advocating and conducting its own research...
3.
Clothier R
Altern Lab Anim . 2011 Feb; 38(6):457-69. PMID: 21275470
Over the past 30 years, FRAME has actively participated in the development, evaluation and validation of in vitro alternative methods through the FRAME Alternatives Laboratory (FAL) in the University of...
4.
Balls M, Clothier R
Altern Lab Anim . 2010 Nov; 38(5):345-53. PMID: 21105753
This response on behalf of FRAME to the European Commission's consultation on the five chapters of the Draft Report on Alternative (Non-animal) Methods for Cosmetics Testing: Current Status and Future...
5.
Balls M, Clothier R
Altern Lab Anim . 2010 Jan; 37(6):631-40. PMID: 20104999
FRAME's historical involvement in the development of the principles of validation, whereby the reliability and relevance of a procedure are established for a specific purpose, and in the practical application...
6.
Scott L, Eskes C, Hoffmann S, Adriaens E, Alepee N, Bufo M, et al.
Toxicol In Vitro . 2009 Jun; 24(1):1-9. PMID: 19490935
In spite of over 20 years of effort, no single in vitro assay has been developed and validated as a full regulatory replacement for the Draize Eye Irritation test. However,...
7.
BeruBe K, Aufderheide M, Breheny D, Clothier R, Combes R, Duffin R, et al.
Altern Lab Anim . 2009 Mar; 37(1):89-141. PMID: 19292579
No abstract available.
8.
Clothier R, Dierickx P, Lakhanisky T, Fabre M, Betanzos M, Curren R, et al.
Altern Lab Anim . 2008 Nov; 36(5):503-19. PMID: 19025321
The main aim of the ACuteTox project (part of the EU 6th Framework programme) is to demonstrate that animal tests for acute systemic toxicity can be replaced by alternative in...
9.
Vinardell M, Benavides T, Mitjans M, Infante M, Clapes P, Clothier R
Food Chem Toxicol . 2008 Nov; 46(12):3837-41. PMID: 18977405
Extensive efforts have been made, recently, to find surfactants with lower irritancy potential than those presently commercially employed in pharmaceutical and cosmetic preparations. Cytotoxic and phototoxic effects of novel mono...
10.
Sjostrom M, Kolman A, Clemedson C, Clothier R
Toxicol In Vitro . 2008 Jun; 22(5):1405-11. PMID: 18514477
The main aim of the ACuteTox project, under EU 6th Framework programme, is to investigate whether animal toxicity tests for acute systemic toxicity could be replaced by a combination of...