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Robert Combes

Explore the profile of Robert Combes including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 65
Citations 175
Followers 0
Related Specialties
Toxicology
Anatomy & Histology
General Surgery
Top 10 Co-Authors
Christina Grindon
Michael Balls
Mark T D Cronin
David W Roberts
John F Garrod
Nirmala Bhogal
Richard Clothier
Jennifer Dandrea
John Garrod
Jan van der Valk
Published In
Altern Lab Anim
Cell Tissue Bank
Toxicol In Vitro
ILAR J
Regul Toxicol Pharmacol
Affiliations
Soon will be listed here.
Recent Articles
1.
Phase 0, including microdosing approaches: Applying the Three Rs and increasing the efficiency of human drug development
Burt T, Vuong L, Baker E, Young G, McCartt A, Bergstrom M, et al.
Altern Lab Anim . 2019 Jan; 46(6):335-346. PMID: 30657329
Phase 0 approaches, including microdosing, involve the use of sub-therapeutic exposures to the tested drugs, thus enabling safer, more-relevant, quicker and cheaper first-in-human (FIH) testing. These approaches also have considerable...
2.
No time like the present - two hundred years of Parkinson's disease
Combes R
Altern Lab Anim . 2017 Jun; 45(2):57-59. PMID: 28598191
No abstract available.
3.
Animal experimentation and alternatives: revealed preferences
Balls M, Combes R
Altern Lab Anim . 2017 Apr; 45(1):1-3. PMID: 28409993
No abstract available.
4.
Animal experimentation: the statistics speak for themselves
Balls M, Combes R
Altern Lab Anim . 2017 Jan; 44(6):511-513. PMID: 28094533
No abstract available.
5.
An approach to minimise dog use in regulatory toxicology: production of a best practice guide to study design
Phillips B, Smith D, Combes R, Descotes G, Jacobsen S, Hack R, et al.
Altern Lab Anim . 2013 Apr; 32 Suppl 1B:447-51. PMID: 23581116
The primary non-rodent species used in toxicology is the dog. It is generally agreed that, for ethical reasons, dog use should be reduced to the minimum consistent with maintaining the...
6.
In vitro models of inhalation toxicity and disease. The report of a FRAME workshop
BeruBe K, Aufderheide M, Breheny D, Clothier R, Combes R, Duffin R, et al.
Altern Lab Anim . 2009 Mar; 37(1):89-141. PMID: 19292579
No abstract available.
7.
An integrated decision-tree testing strategy for repeat dose toxicity with respect to the requirements of the EU REACH legislation
Grindon C, Combes R, Cronin M, Roberts D, Garrod J
Altern Lab Anim . 2008 Dec; 36 Suppl 1:139-47. PMID: 19025337
This paper presents some results of a joint research project conducted by FRAME and Liverpool John Moores University, and sponsored by Defra, on the status of alternatives to animal testing...
8.
Integrated decision-tree testing strategies for developmental and reproductive toxicity with respect to the requirements of the EU REACH legislation
Grindon C, Combes R, Cronin M, Roberts D, Garrod J
Altern Lab Anim . 2008 Dec; 36 Suppl 1:123-38. PMID: 19025336
Liverpool John Moores University and FRAME conducted a research project, sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation...
9.
An integrated decision-tree testing strategy for eye irritation with respect to the requirements of the EU REACH legislation
Grindon C, Combes R, Cronin M, Roberts D, Garrod J
Altern Lab Anim . 2008 Dec; 36 Suppl 1:111-22. PMID: 19025335
This paper presents some results of a joint research project, sponsored by Defra and conducted by FRAME and Liverpool John Moores University, on the status of alternatives to animal testing...
10.
Integrated decision-tree testing strategies for acute systemic toxicity and toxicokinetics with respect to the requirements of the EU REACH legislation
Combes R, Grindon C, Cronin M, Roberts D, Garrod J
Altern Lab Anim . 2008 Dec; 36 Suppl 1:91-109. PMID: 19025334
Liverpool John Moores University and FRAME conducted a joint research project, sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration,...