Richard B Presland
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Explore the profile of Richard B Presland including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Kalus A, Fredericks L, Hacker B, Dommisch H, Presland R, Kimball J, et al.
BMC Oral Health
. 2009 Aug;
9:21.
PMID: 19712472
Background: Human beta-defensins (hBDs) are antimicrobial peptides with a role in innate immune defense. Our laboratory previously showed that a single nucleotide polymorphism (SNP) in the 5' untranslated region of...
12.
Fallon P, Sasaki T, Sandilands A, Campbell L, Saunders S, Mangan N, et al.
Nat Genet
. 2009 Apr;
41(5):602-8.
PMID: 19349982
Loss-of-function mutations in the FLG (filaggrin) gene cause the semidominant keratinizing disorder ichthyosis vulgaris and convey major genetic risk for atopic dermatitis (eczema), eczema-associated asthma and other allergic phenotypes. Several...
13.
Denecker G, Hoste E, Gilbert B, Hochepied T, Ovaere P, Lippens S, et al.
Nat Cell Biol
. 2007 May;
9(6):666-74.
PMID: 17515931
Caspase-14 belongs to a conserved family of aspartate-specific proteinases. Its expression is restricted almost exclusively to the suprabasal layers of the epidermis and the hair follicles. Moreover, the proteolytic activation...
14.
Fatherazi S, Presland R, Belton C, Goodwin P, Al-Qutub M, Trbic Z, et al.
Pflugers Arch
. 2006 Oct;
453(6):879-89.
PMID: 17031666
We previously demonstrated that high external [Ca(2+)] activated two Ca(2+) currents in human gingival keratinocytes (HGKs): an initial small I(CRAC)-like current and a second large nonspecific cation current (Fatherazi S,...
15.
Park K, Kuechle M, Choe Y, Craik C, Lawrence O, Presland R
Biochem Biophys Res Commun
. 2006 Jul;
347(4):941-8.
PMID: 16854378
Caspase-14 is a cysteine endoproteinase that is expressed in the epidermis and a limited number of other tissues. It is activated during keratinocyte differentiation by zymogen processing, but its precise...
16.
Smith F, Irvine A, Terron-Kwiatkowski A, Sandilands A, Campbell L, Zhao Y, et al.
Nat Genet
. 2006 Jan;
38(3):337-42.
PMID: 16444271
Ichthyosis vulgaris (OMIM 146700) is the most common inherited disorder of keratinization and one of the most frequent single-gene disorders in humans. The most widely cited incidence figure is 1...
17.
Cai S, Fatherazi S, Presland R, Belton C, Roberts F, Goodwin P, et al.
Pflugers Arch
. 2005 Nov;
452(1):43-52.
PMID: 16283206
External calcium ion concentration is a major regulator of epidermal keratinocyte differentiation in vitro and probably also in vivo. Regulation of calcium-induced differentiation changes is proposed to occur via an...
18.
Cai S, Fatherazi S, Presland R, Belton C, Izutsu K
J Dermatol Sci
. 2005 Jul;
40(1):21-8.
PMID: 16051466
Background: Extracellular calcium is an important regulator of keratinocyte differentiation. An increase in intracellular calcium ion concentration is required for activation of calcium-induced keratinocyte differentiation. The signaling elements in this...
19.
Wang H, Presland R, Piepkorn M
Arch Dermatol
. 2005 Feb;
141(2):177-80.
PMID: 15724013
Objective: To determine the frequency at which the CDKN2A coding region is mutated in the atypical nevi of persons with sporadic melanoma. Design: DNA samples, isolated by laser-captured microdissection of...
20.
Presland R, Fleckman P
Methods Mol Biol
. 2004 Oct;
289:273-86.
PMID: 15502192
The tetracycline-regulated expression system developed by Gossen and Bujard is a powerful genetic tool that permits the expression of any gene construct introduced into either cultured cells or transgenic animals...