Richard B Pearson
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Explore the profile of Richard B Pearson including associated specialties, affiliations and a list of published articles.
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96
Citations
4989
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Recent Articles
1.
Maclachlan K, Gitareja K, Kang J, Cuddihy A, Cao Y, Hein N, et al.
Mol Ther Oncol
. 2024 Apr;
32(1):200771.
PMID: 38596309
The high rates of protein synthesis and processing render multiple myeloma (MM) cells vulnerable to perturbations in protein homeostasis. The induction of proteotoxic stress by targeting protein degradation with proteasome...
2.
Behrens K, Brajanovski N, Xu Z, Viney E, DiRago L, Hediyeh-Zadeh S, et al.
Sci Adv
. 2024 Mar;
10(10):eadj8803.
PMID: 38457494
Philadelphia chromosome-positive B cell acute lymphoblastic leukemia (B-ALL), characterized by the fusion gene, remains a poor prognosis cancer needing new therapeutic approaches. Transcriptomic profiling identified up-regulation of oncogenic transcription factors...
3.
Feng Y, Yang T, Zhu J, Li M, Doyle M, Ozcoban V, et al.
Nat Commun
. 2023 May;
14(1):2697.
PMID: 37188662
Spatial proteomics technologies have revealed an underappreciated link between the location of cells in tissue microenvironments and the underlying biology and clinical features, but there is significant lag in the...
4.
Hannan K, Soo P, Wong M, Lee J, Hein N, Poh P, et al.
Cell Rep
. 2022 Nov;
41(5):111571.
PMID: 36323262
The nucleolar surveillance pathway monitors nucleolar integrity and responds to nucleolar stress by mediating binding of ribosomal proteins to MDM2, resulting in p53 accumulation. Inappropriate pathway activation is implicated in...
5.
Zhu H, Chan K, Huang X, Cerra C, Blake S, Trigos A, et al.
Elife
. 2022 Jun;
11.
PMID: 35758651
Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts as a tumor-suppressive mechanism that must be overcome during transformation. We previously...
6.
Smith L, Parmenter T, Kleinschmidt M, Kusnadi E, Kang J, Martin C, et al.
Nat Commun
. 2022 Mar;
13(1):1100.
PMID: 35232962
Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately results in relapse. This residual disease is often characterized by non-genetic adaptive...
7.
Koltowska K, Okuda K, Gloger M, Rondon-Galeano M, Mason E, Xuan J, et al.
Nat Cell Biol
. 2021 Nov;
23(11):1136-1147.
PMID: 34750583
The development of a functional vasculature requires the coordinated control of cell fate, lineage differentiation and network growth. Cellular proliferation is spatiotemporally regulated in developing vessels, but how this is...
8.
Kang J, Brajanovski N, Chan K, Xuan J, Pearson R, Sanij E
Signal Transduct Target Ther
. 2021 Aug;
6(1):323.
PMID: 34462428
Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly...
9.
Lawrence M, Porter L, Choo N, Pook D, Grummet J, Pezaro C, et al.
Mol Cancer Ther
. 2021 Aug;
20(11):2140-2150.
PMID: 34413130
Monotherapy with PARP inhibitors is effective for the subset of castrate-resistant prostate cancer (CRPC) with defects in homologous recombination (HR) DNA repair. New treatments are required for the remaining tumors,...
10.
Domostegui A, Peddigari S, Mercer C, Iannizzotto F, Rodriguez M, Garcia-Cajide M, et al.
Blood
. 2021 Jan;
137(24):3351-3364.
PMID: 33512431
MYC-driven B-cell lymphomas are addicted to increased levels of ribosome biogenesis (RiBi), offering the potential for therapeutic intervention. However, it is unclear whether inhibition of RiBi suppresses lymphomagenesis by decreasing...