Richard A Thompson
Overview
Explore the profile of Richard A Thompson including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
201
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ekdahl A, Weidolf L, Baginski M, Morikawa Y, Thompson R, Wilson I
Arch Toxicol
. 2018 Aug;
92(9):2819-2828.
PMID: 30094548
The metabolic fate of the human hepatotoxin fenclozic acid ([2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid) (Myalex) was studied in normal and bile-cannulated chimeric mice with a humanized liver, following oral administration of 10 mg/kg....
2.
Iegre J, Hayes M, Thompson R, Weidolf L, Isin E
Drug Metab Dispos
. 2016 Feb;
44(5):732-40.
PMID: 26868617
As part of the drug discovery and development process, it is important to understand the human metabolism of a candidate drug prior to clinical studies. Preclinical in vitro and in...
3.
Thompson R, Isin E, Ogese M, Mettetal J, Williams D
Chem Res Toxicol
. 2016 Jan;
29(4):505-33.
PMID: 26735163
Although idiosyncratic adverse drug reactions are rare, they are still a major concern to patient safety. Reactive metabolites are widely accepted as playing a pivotal role in the pathogenesis of...
4.
Ahlqvist M, Leandersson C, Hayes M, Zamora I, Thompson R
Rapid Commun Mass Spectrom
. 2015 Oct;
29(21):2083-9.
PMID: 26443410
Rationale: Structural information on metabolites obtained in relevant biological systems can have considerable impact on the design of new drug candidates. However, with demanding turnaround times, the amount of available...
5.
Kenna J, Stahl S, Eakins J, Foster A, Andersson L, Bergare J, et al.
J Pharmacol Exp Ther
. 2014 Dec;
352(2):281-90.
PMID: 25467130
Drug-induced liver injury has been observed in patients treated with the endothelin receptor antagonists sitaxentan and bosentan, but not following treatment with ambrisentan. The aim of our studies was to...
6.
Wan H, Thompson R
Drug Discov Today Technol
. 2014 Jul;
2(2):171-8.
PMID: 24981845
The high separation efficiency of capillary electrophoresis (CE), combined with the high selectivity and sensitivity of mass spectrometry (MS) detection offers the potential of unique resolving power and high-throughput capacity...
7.
Thompson R, Isin E, Li Y, Weidolf L, Page K, Wilson I, et al.
Chem Res Toxicol
. 2012 Jun;
25(8):1616-32.
PMID: 22646477
Idiosyncratic adverse drug reactions (IADRs) in humans can result in a broad range of clinically significant toxicities leading to attrition during drug development as well as postlicensing withdrawal or labeling....
8.
Isin E, Elmore C, Nilsson G, Thompson R, Weidolf L
Chem Res Toxicol
. 2012 Mar;
25(3):532-42.
PMID: 22372867
As part of the drug discovery and development process, it is important to understand the fate of the drug candidate in humans and the relevance of the animal species used...
9.
Plowright A, Johnstone C, Kihlberg J, Pettersson J, Robb G, Thompson R
Drug Discov Today
. 2011 Oct;
17(1-2):56-62.
PMID: 21963616
In drug discovery, the central process of constructing and testing hypotheses, carefully conducting experiments and analysing the associated data for new findings and information is known as the design-make-test-analyse cycle....
10.
Nordberg H, Jerndal G, Thompson R
Bioanalysis
. 2011 Sep;
3(17):1963-73.
PMID: 21899505
Background: A high-throughput bioanalytical methodology for analysis and quantification of lipophilic pharmaceutical compounds in plasma using liquid-liquid extraction (LLE) was developed. Results: A fast and robust alternative to the widely...