Richard A Oram
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Explore the profile of Richard A Oram including associated specialties, affiliations and a list of published articles.
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94
Citations
2702
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Recent Articles
1.
Squires S, Weedon M, Oram R
Biomed Phys Eng Express
. 2025 Feb;
11(2).
PMID: 40020248
. Polygenic risk scores (PRS) summarise genetic information into a single number with clinical and research uses. Deep learning (DL) has revolutionised multiple fields, however, the impact of DL on...
2.
Sims E, Cuthbertson D, Ferrat L, Bosi E, Evans-Molina C, DiMeglio L, et al.
Diabetologia
. 2025 Feb;
PMID: 40016443
Aims/hypothesis: Accurate understanding of type 1 diabetes risk is critical for optimisation of counselling, monitoring and interventions, yet even within established staging classifications, individual time to clinical disease varies. Previous...
3.
A type 1 diabetes prediction model has utility across multiple screening settings with recalibration
Templeman E, Ferrat L, Parikh H, You L, Triolo T, Steck A, et al.
Res Sq
. 2025 Feb;
PMID: 39975907
Background: Accurate type 1 diabetes prediction is important to facilitate screening for pre-clinical type 1 diabetes to enable potential early disease-modifying interventions and to reduce the risk of severe presentation...
4.
Luckett A, Oram R, Deutsch A, Ortega H, Fraser D, Ashok K, et al.
medRxiv
. 2025 Jan;
PMID: 39867414
Type 1 diabetes (T1D) polygenic risk scores (PRS) are effective tools for discriminating T1D from other diabetes types and predicting T1D risk, with applications in screening and intervention trials. A...
5.
Liu T, Sankareswaran A, Paterson G, Fraser D, Hodgson S, Huang Q, et al.
Sci Rep
. 2025 Jan;
15(1):1168.
PMID: 39805939
Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. Polygenic...
6.
Arni A, Fraser D, Sharp S, Oram R, Johnson M, Weedon M, et al.
Sci Rep
. 2024 Dec;
14(1):31044.
PMID: 39730838
A Type 1 Diabetes Genetic Risk Score (T1DGRS) aids diagnosis and prediction of Type 1 Diabetes (T1D). While traditionally derived from imputed array genotypes, Whole Genome Sequencing (WGS) provides a...
7.
Locke J, Spurrier B, Laver T, Houghton J, Colclough K, Weedon M, et al.
J Transl Med
. 2024 Dec;
22(1):1128.
PMID: 39707450
No abstract available.
8.
McGrail C, Chiou J, Elgamal R, Egamal R, Luckett A, Oram R, et al.
Diabetes Care
. 2024 Dec;
48(2):202-211.
PMID: 39626097
Objective: More than 10% of patients with type 1 diabetes (T1D) do not have high-risk HLA-DR3 or -DR4 haplotypes with distinct clinical features, such as later onset and reduced insulin...
9.
Ogishi M, Kitaoka K, Good-Jacobson K, Rinchai D, Zhang B, Wang J, et al.
Immunity
. 2024 Nov;
57(12):2790-2807.e15.
PMID: 39603236
T follicular helper (Tfh) cells abundantly express the immunoreceptor programmed cell death protein 1 (PD-1), and the impact of PD-1 deficiency on antibody (Ab)-mediated immunity in mice is associated with...
10.
Type 1 Diabetes Genetic Risk Contributes to Phenotypic Presentation in Monogenic Autoimmune Diabetes
Luckett A, Hawkes G, Green H, De Franco E, Hagopian W, Roep B, et al.
Diabetes
. 2024 Nov;
74(2):243-248.
PMID: 39531505
There is variability in early-onset autoimmune diabetes presentation in individuals with monogenic autoimmunity; the mechanism(s) underlying this is unclear. We examined whether type 1 diabetes (T1D) polygenic risk contributes to...