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Richard A Hopkins

Explore the profile of Richard A Hopkins including associated specialties, affiliations and a list of published articles. Areas
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Articles 49
Citations 751
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Recent Articles
1.
Tan E, Hopkins R, Lim C, Jamuar S, Ong C, Thoon K, et al.
J Clin Invest . 2020 Aug; 130(11):5817-5832. PMID: 32750042
Although IKK-β has previously been shown as a negative regulator of IL-1β secretion in mice, this role has not been proven in humans. Genetic studies of NF-κB signaling in humans...
2.
Ahl P, Hopkins R, Xiang W, Au B, Kaliaperumal N, Fairhurst A, et al.
Commun Biol . 2020 Jun; 3(1):305. PMID: 32533056
A complex interaction of anabolic and catabolic metabolism underpins the ability of leukocytes to mount an immune response. Their capacity to respond to changing environments by metabolic reprogramming is crucial...
3.
VeDepo M, Buse E, Paul A, Converse G, Hopkins R
Cardiovasc Eng Technol . 2019 Oct; 10(4):628-637. PMID: 31650518
Purpose: Conventional methods of seeding decellularized heart valves for heart valve tissue engineering have led to inconsistent results in interstitial cellular repopulation, particularly of the distal valve leaflet, and notably...
4.
Li D, Chiu G, Lipe B, Hopkins R, Lillis J, Ashton J, et al.
Blood Adv . 2019 Apr; 3(7):1011-1026. PMID: 30940636
Hematopoietic stem progenitor cells (HSPCs) reside in the bone marrow (BM) hematopoietic "niche," a special 3-dimensional (3D) microenvironment that regulates HSPC self-renewal and multipotency. In this study, we evaluated a...
5.
Li D, Lin T, Lipe B, Hopkins R, Shinogle H, Aljitawi O
Leuk Res . 2018 Aug; 72:105-112. PMID: 30130689
Acute myeloid leukemia (AML) relapse results from the survival of chemotherapy-resistant and quiescent leukemia stem cells (LSC). These LSCs reside in the bone marrow microenvironment, comprised of other cells and...
6.
VeDepo M, Detamore M, Hopkins R, Converse G
J Tissue Eng . 2017 Sep; 8:2041731417726327. PMID: 28890780
The tissue-engineered heart valve portends a new era in the field of valve replacement. Decellularized heart valves are of great interest as a scaffold for the tissue-engineered heart valve due...
7.
Converse G, Li D, Buse E, Hopkins R, Aljitawi O
Methods Mol Biol . 2017 Aug; 1577:25-33. PMID: 28786033
Scaffolds, both natural and synthetic, used in tissue engineering provide mechanical support to cells. Tissue decellularization has been used to provide natural extracellular matrix scaffolds for tissue engineering purposes. In...
8.
Jadalannagari S, Converse G, McFall C, Buse E, Filla M, Villar M, et al.
PLoS One . 2017 Feb; 12(2):e0172098. PMID: 28222169
In tissue engineering, an ideal scaffold attracts and supports cells thus providing them with the necessary mechanical support and architecture as they reconstruct new tissue in vitro and in vivo....
9.
VeDepo M, Buse E, Quinn R, Williams T, Detamore M, Hopkins R, et al.
Acta Biomater . 2017 Jan; 50:249-258. PMID: 28069510
Statement Of Significance: The decellularized heart valve offers potential as an improved heart valve substitute and as a scaffold for the tissue engineered heart valve; however, the consequences of processing...
10.
Quinn R, Bert A, Converse G, Buse E, Hilbert S, Drake W, et al.
J Thorac Cardiovasc Surg . 2016 Sep; 152(4):1156-1165.e4. PMID: 27641300
Background: Cardiac allometric organ growth after pediatric valve replacement can lead to patient-prosthesis size mismatch and valve re-replacement, which could be mitigated with allogeneic decellularized pulmonary valves treated with collagen...