Ricardo N Ramirez
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Explore the profile of Ricardo N Ramirez including associated specialties, affiliations and a list of published articles.
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21
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1494
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Recent Articles
1.
Tremblay F, Xiong Q, Shah S, Ko C, Kelly K, Morrison M, et al.
Nat Med
. 2025 Feb;
PMID: 39930141
Epigenetic editing holds the promise of durable therapeutic effects by silencing disease-causing genes without changing the underlying DNA sequence. In this study, we designed an epigenetic editor to target human...
2.
Zhang W, Leng F, Wang X, Ramirez R, Park J, Benoist C, et al.
Nature
. 2023 Nov;
624(7991):433-441.
PMID: 38030726
FOXP3 is a transcription factor that is essential for the development of regulatory T cells, a branch of T cells that suppress excessive inflammation and autoimmunity. However, the molecular mechanisms...
3.
Zhang W, Leng F, Wang X, Ramirez R, Park J, Benoist C, et al.
bioRxiv
. 2023 Nov;
PMID: 37986949
FoxP3 is a transcription factor (TF) essential for development of regulatory T cells (Tregs), a branch of T cells that suppress excessive inflammation and autoimmunity . Molecular mechanisms of FoxP3,...
4.
Leon J, Chowdhary K, Zhang W, Ramirez R, Andre I, Hur S, et al.
Cell Rep
. 2023 Aug;
42(8):113018.
PMID: 37605532
Mutations of the transcription factor FoxP3 in patients with "IPEX" (immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) disrupt regulatory T cells (Treg), causing an array of multiorgan autoimmunity. To understand the...
5.
Hanna B, Wang G, Galvan-Pena S, Mann A, Ramirez R, Munoz-Rojas A, et al.
Immunity
. 2023 Feb;
56(4):829-846.e8.
PMID: 36822206
Specific microbial signals induce the differentiation of a distinct pool of RORγ regulatory T (Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations of microbiota-dependent Treg cells that...
6.
Leng F, Zhang W, Ramirez R, Leon J, Zhong Y, Hou L, et al.
Immunity
. 2022 Aug;
55(8):1354-1369.e8.
PMID: 35926508
FoxP3 is an essential transcription factor (TF) for immunologic homeostasis, but how it utilizes the common forkhead DNA-binding domain (DBD) to perform its unique function remains poorly understood. We here...
7.
Ramirez R, Chowdhary K, Leon J, Mathis D, Benoist C
Sci Immunol
. 2022 Jan;
7(67):eabj9836.
PMID: 35030035
Gene expression programs are specified by higher-order chromatin structure and enhancer-promoter loops (EPLs). T regulatory cell (T) identity is dominantly specified by the transcription factor (TF) FoxP3, whose mechanism of...
8.
Kim E, Paik D, Ramirez R, Biggs D, Park Y, Kwon H, et al.
Immunity
. 2021 Dec;
55(1):145-158.e7.
PMID: 34879222
Children with autism spectrum disorders often display dysregulated immune responses and related gastrointestinal symptoms. However, the underlying mechanisms leading to the development of both phenotypes have not been elucidated. Here,...
9.
Bansal K, Michelson D, Ramirez R, Viny A, Levine R, Benoist C, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(38).
PMID: 34518235
Aire controls immunological tolerance by driving promiscuous expression of a large swath of the genome in medullary thymic epithelial cells (mTECs). Its molecular mechanism remains enigmatic. High-resolution chromosome-conformation capture (Hi-C)...
10.
Li C, Wang G, Sivasami P, Ramirez R, Zhang Y, Benoist C, et al.
Cell Metab
. 2021 Jul;
33(8):1610-1623.e5.
PMID: 34256015
The visceral adipose tissue (VAT) of lean mice hosts a unique population of regulatory T cells (Tregs) that have a distinct transcriptome and T cell receptor (TCR) repertoire and regulate...