Rhonda Grebe
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Explore the profile of Rhonda Grebe including associated specialties, affiliations and a list of published articles.
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43
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1441
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Recent Articles
1.
Edwards M, McLeod D, Grebe R, Bhutto I, Dahake R, Crumley K, et al.
Front Ophthalmol (Lausanne)
. 2024 Jul;
2:994566.
PMID: 38983545
Choroideremia (CHM) is a recessive, X-linked disease that affects 1 in 50,000 people worldwide. CHM causes night blindness in teenage years with vision loss progressing over the next two to...
2.
Naik P, Grebe R, Bhutto I, McLeod D, Edwards M
Transl Vis Sci Technol
. 2024 Feb;
13(2):10.
PMID: 38349778
Purpose: Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration with multifactorial etiology and no well-established treatment. A model recapitulating the hallmarks would serve as a key...
3.
Edwards M, McLeod D, Shen M, Grebe R, Sunness J, Bhutto I, et al.
Invest Ophthalmol Vis Sci
. 2023 Mar;
64(3):2.
PMID: 36862121
Purpose: Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly worldwide. Clinical imaging and histopathologic studies are crucial to understanding disease pathology. This study combined clinical...
4.
Gupta U, Ghosh S, Wallace C, Shang P, Xin Y, Nair A, et al.
Autophagy
. 2022 Apr;
19(1):92-111.
PMID: 35473441
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, we report that in retinal pigmented...
5.
Shang P, Stepicheva N, Teel K, McCauley A, Fitting C, Hose S, et al.
Commun Biol
. 2021 Jul;
4(1):850.
PMID: 34239035
The retinal pigmented epithelium (RPE) is a monolayer of multifunctional cells located at the back of the eye. High membrane turnover and polarization, including formation of actin-based apical microvilli, are...
6.
Park T, Zimmerlin L, Evans-Moses R, Thomas J, Huo J, Kanherkar R, et al.
Nat Commun
. 2020 Mar;
11(1):1195.
PMID: 32139672
Here, we report that the functionality of vascular progenitors (VP) generated from normal and disease-primed conventional human induced pluripotent stem cells (hiPSC) can be significantly improved by reversion to a...
7.
Yazdankhah M, Shang P, Ghosh S, Bhutto I, Stepicheva N, Grebe R, et al.
Autophagy
. 2019 Aug;
16(6):1130-1142.
PMID: 31462148
Abbreviations: ACTB: actin, beta; CCND3: cyclin 3; CDK6: cyclin-dependent kinase 6; CHQ: chloroquine; COL4A1: collagen, type IV, alpha 1; CRYBA1: crystallin, beta A1; DAPI: 4'6-diamino-2-phenylindole; EGFR: epidermal growth factor receptor;...
8.
Grebe R, Mughal I, Bryden W, McLeod S, Edwards M, Hageman G, et al.
Exp Eye Res
. 2019 Feb;
181:252-262.
PMID: 30807744
The choriocapillaris is the source of nutrients and oxygen for photoreceptors, which consume more oxygen per gram of tissue than any other cell in the body. The purpose of this...
9.
Wahlin K, Maruotti J, Sripathi S, Ball J, Angueyra J, Kim C, et al.
Sci Rep
. 2017 Apr;
7(1):766.
PMID: 28396597
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem...
10.
Edwards M, McLeod D, Bhutto I, Grebe R, Duffy M, Lutty G
Invest Ophthalmol Vis Sci
. 2017 Mar;
58(3):1352-1367.
PMID: 28249091
Purpose: Müller cells create the external limiting membrane (ELM) by forming junctions with photoreceptor cells. This study evaluated the relationship between focal photoreceptors and RPE loss in geographic atrophy (GA)...