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Renee Paradis

Explore the profile of Renee Paradis including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 541
Followers 0
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Recent Articles
1.
Vitry G, Paulin R, Grobs Y, Lampron M, Shimauchi T, Lemay S, et al.
Am J Respir Crit Care Med . 2020 Oct; 203(5):614-627. PMID: 33021405
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by abnormally elevated pulmonary pressures and right ventricular failure. Excessive proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells...
2.
Lampron M, Vitry G, Nadeau V, Grobs Y, Paradis R, Samson N, et al.
Arterioscler Thromb Vasc Biol . 2020 Jan; 40(3):783-801. PMID: 31969012
Objective: Pulmonary arterial hypertension (PAH) is a fatal disease characterized by the narrowing of pulmonary arteries (PAs). It is now established that this phenotype is associated with enhanced PA smooth...
3.
Bourgeois A, Bonnet S, Breuils-Bonnet S, Habbout K, Paradis R, Tremblay E, et al.
Arterioscler Thromb Vasc Biol . 2019 May; 39(8):1667-1681. PMID: 31092016
Objective: Pulmonary arterial hypertension (PAH) is a debilitating disease associated with progressive vascular remodeling of distal pulmonary arteries leading to elevation of pulmonary artery pressure, right ventricular hypertrophy, and death....
4.
Bourgeois A, Lambert C, Habbout K, Ranchoux B, Paquet-Marceau S, Trinh I, et al.
J Mol Med (Berl) . 2018 Jan; 96(2):223-235. PMID: 29290032
Key Messages: FOXM1 is overexpressed in human PAH-PASMCs and PAH animal models. FOXM1 promotes PAH-PASMC proliferation and resistance to apoptosis. Pharmacological inhibition of FOXM1 improves established PAH in the MCT...
5.
Nadeau V, Potus F, Boucherat O, Paradis R, Tremblay E, Iglarz M, et al.
Pulm Circ . 2017 Oct; 8(1):2045893217741429. PMID: 29064353
Dysregulated metabolism and rarefaction of the capillary network play a critical role in pulmonary arterial hypertension (PAH) etiology. They are associated with a decrease in perfusion of the lungs, skeletal...
6.
Boucherat O, Chabot S, Paulin R, Trinh I, Bourgeois A, Potus F, et al.
Sci Rep . 2017 Jul; 7(1):4546. PMID: 28674407
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with limited therapeutic options. Although exposed to stressful conditions, pulmonary artery (PA) smooth muscle cells (PASMCs) exhibit a "cancer-like" pro-proliferative and...
7.
Ruffenach G, Chabot S, Tanguay V, Courboulin A, Boucherat O, Potus F, et al.
Am J Respir Crit Care Med . 2016 May; 194(10):1273-1285. PMID: 27149112
Rationale: Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). This is sustained in time by the down-regulation of microRNA (miR)-204. In systemic...
8.
Meloche J, Potus F, Vaillancourt M, Bourgeois A, Johnson I, Deschamps L, et al.
Circ Res . 2015 Jul; 117(6):525-35. PMID: 26224795
Rationale: Pulmonary arterial hypertension (PAH) is a vasculopathy characterized by enhanced pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and suppressed apoptosis. Decreased expression of microRNA-204 has been associated to...
9.
Potus F, Ruffenach G, Dahou A, Thebault C, Breuils-Bonnet S, Tremblay E, et al.
Circulation . 2015 Jul; 132(10):932-43. PMID: 26162916
Background: Right ventricular (RV) failure is the most important factor of both morbidity and mortality in pulmonary arterial hypertension (PAH). However, the underlying mechanisms resulting in the failed RV in...
10.
Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, et al.
J Comp Neurol . 2014 Mar; 522(12):2707-28. PMID: 24610630
Transplantation of human neural progenitor cells (NPCs) into the brain or spinal cord to replace lost cells, modulate the injury environment, or create a permissive milieu to protect and regenerate...