Remy Kachadourian
Overview
Explore the profile of Remy Kachadourian including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
490
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Recent Articles
1.
Szakacs G, Hall M, Gottesman M, Boumendjel A, Kachadourian R, Day B, et al.
Chem Rev
. 2014 Apr;
114(11):5753-74.
PMID: 24758331
No abstract available.
2.
Valdameri G, Gauthier C, Terreux R, Kachadourian R, Day B, Winnischofer S, et al.
J Med Chem
. 2012 Mar;
55(7):3193-200.
PMID: 22449016
ABCG2 plays a major role in anticancer-drug efflux and related tumor multidrug resistance. Potent and selective ABCG2 inhibitors with low cytotoxicity were investigated among a series of 44 chalcones and...
3.
Kachadourian R, Day B, Pugazhenti S, Franklin C, Genoux-Bastide E, Mahaffey G, et al.
J Med Chem
. 2012 Jan;
55(3):1382-8.
PMID: 22239485
Chalcones continue to attract considerable interest due to their anti-inflammatory and antiangiogenic properties. We recently reported the ability of 2',5'-dihydroxychalcone (2',5'-DHC) to induce both breast cancer resistance protein-mediated export of...
4.
Brechbuhl H, Kachadourian R, Min E, Chan D, Day B
Toxicol Appl Pharmacol
. 2011 Aug;
258(1):1-9.
PMID: 21856323
We hypothesized that flavonoid-induced glutathione (GSH) efflux through multi-drug resistance proteins (MRPs) and subsequent intracellular GSH depletion is a viable mechanism to sensitize cancer cells to chemotherapies. This concept was...
5.
Kachadourian R, Pugazhenthi S, Velmurugan K, Backos D, Franklin C, McCord J, et al.
Free Radic Biol Med
. 2011 Jun;
51(6):1146-54.
PMID: 21712085
Hydroxychalcones are naturally occurring compounds that continue to attract considerable interest because of their anti-inflammatory and antiangiogenic properties. They have been reported to inhibit the synthesis of the inducible nitric...
6.
Brechbuhl H, Gould N, Kachadourian R, Riekhof W, Voelker D, Day B
J Biol Chem
. 2010 Mar;
285(22):16582-7.
PMID: 20332504
Glutathione (GSH) transport is vital for maintenance of intracellular and extracellular redox balance. Only a few human proteins have been identified as transporters of GSH, glutathione disulfide (GSSG) and/or GSH...
7.
Kachadourian R, Brechbuhl H, Ruiz-Azuara L, Gracia-Mora I, Day B
Toxicology
. 2009 Dec;
268(3):176-83.
PMID: 20026372
Casiopeínas are a series of mixed chelate copper complexes that are being evaluated as anticancer agents. Their effects in the cell include oxidative damage and mitochondrial dysfunction, yet the molecular...
8.
Leitner H, Kachadourian R, Day B
Biochem Pharmacol
. 2007 Jun;
74(12):1677-85.
PMID: 17585883
The ATP-binding cassette (ABC) class of proteins is one of the most functionally diverse transporter families found in biological systems. Although the abundance of ABC proteins varies between species, they...
9.
Kachadourian R, Leitner H, Day B
Int J Oncol
. 2007 Jun;
31(1):161-8.
PMID: 17549417
Adjuvant therapies that enhance the anti-tumor effects of cis-diammineplatinum(II) dichloride (cisplatin, CDDP) are actively being pursued. Growing evidence supports the involvement of mitochondrial dysfunction in the anti-cancer effect of cisplatin....
10.
Kachadourian R, Day B
Free Radic Biol Med
. 2006 Jun;
41(1):65-76.
PMID: 16781454
The ability of a number of flavonoids to induce glutathione (GSH) depletion was measured in lung (A549), myeloid (HL-60), and prostate (PC-3) human tumor cells. The hydroxychalcone (2'-HC) and the...