Remon van Geel
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Explore the profile of Remon van Geel including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
266
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Recent Articles
1.
Wijdeven M, van Geel R, Hoogenboom J, Verkade J, Janssen B, Hurkmans I, et al.
MAbs
. 2022 May;
14(1):2078466.
PMID: 35634725
Antibody-drug conjugates (ADCs) are increasingly powerful medicines for targeted cancer therapy. Inspired by the trend to further improve their therapeutic index by generation of homogenous ADCs, we report here how...
2.
Verkade J, Wijdeven M, van Geel R, Janssen B, van Berkel S, van Delft F
Antibodies (Basel)
. 2019 Sep;
7(3).
PMID: 31544884
The conflict of interest section of the published paper [1] has been updated as follows[...].
3.
Verkade J, Wijdeven M, van Geel R, Janssen B, van Berkel S, van Delft F
Antibodies (Basel)
. 2019 Sep;
7(1).
PMID: 31544864
Despite tremendous efforts in the field of targeted cancer therapy with antibody-drug conjugates (ADCs), attrition rates have been high. Historically, the priority in ADC development has been the selection of...
4.
van Geel R, Wijdeven M, Heesbeen R, Verkade J, Wasiel A, van Berkel S, et al.
Bioconjug Chem
. 2015 Jun;
26(11):2233-42.
PMID: 26061183
A robust, generally applicable, nongenetic technology is presented to convert monoclonal antibodies into stable and homogeneous ADCs. Starting from a native (nonengineered) mAb, a chemoenzymatic protocol allows for the highly...
5.
Preventing thiol-yne addition improves the specificity of strain-promoted azide-alkyne cycloaddition
van Geel R, Pruijn G, van Delft F, Boelens W
Bioconjug Chem
. 2012 Mar;
23(3):392-8.
PMID: 22372991
The 1,3-dipolar cycloaddition of azides with ring-strained alkynes is one of the few bioorthogonal reactions suitable for specific biomolecule labeling in complex biological systems. Nevertheless, azide-independent labeling of proteins by...
6.
van Geel R, Debets M, Lowik D, Pruijn G, Boelens W
Amino Acids
. 2011 Dec;
43(3):1251-63.
PMID: 22180026
Transglutaminase 2 (TG2) is a Ca(2+)-dependent enzyme able to catalyze the formation of ε(γ-glutamyl)-lysine crosslinks between polypeptides, resulting in high molecular mass multimers. We have developed a bioorthogonal chemical method...
7.
van den Akker J, VanBavel E, van Geel R, Matlung H, Guvenc Tuna B, Janssen G, et al.
PLoS One
. 2011 Sep;
6(8):e23067.
PMID: 21901120
While inward remodeling of small arteries in response to low blood flow, hypertension, and chronic vasoconstriction depends on type 2 transglutaminase (TG2), the mechanisms of action have remained unresolved. We...
8.
Dirks R, van Geel R, Hensen S, van Genesen S, Lubsen N
PLoS One
. 2010 Apr;
5(4):e10158.
PMID: 20405018
Background: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in...