Reisa A Sperling
Overview
Explore the profile of Reisa A Sperling including associated specialties, affiliations and a list of published articles.
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371
Citations
31952
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Recent Articles
21.
Honig L, Sabbagh M, van Dyck C, Sperling R, Hersch S, Matta A, et al.
Alzheimers Res Ther
. 2024 Jul;
16(1):159.
PMID: 38987826
No abstract available.
22.
Boyle R, Townsend D, Klinger H, Scanlon C, Yuan Z, Coughlan G, et al.
Alzheimers Res Ther
. 2024 Jul;
16(1):148.
PMID: 38961512
Background: Leveraging Alzheimer's disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to AD pathology in-vivo. Here, we applied latent class...
23.
Rosenzweig N, Kleemann K, Rust T, Carpenter M, Grucci M, Aronchik M, et al.
Nat Med
. 2024 Jul;
30(10):2990-3003.
PMID: 38961225
APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non-APOE4 carriers. Leveraging single-cell...
24.
Dubbelman M, Diez I, Gonzalez C, Amariglio R, Becker J, Chhatwal J, et al.
Front Aging Neurosci
. 2024 Jun;
16:1420290.
PMID: 38934017
Background: Changes in everyday functioning constitute a clinically meaningful outcome, even in the early stages of Alzheimer's disease. Performance-based assessments of everyday functioning might help uncover these early changes. We...
25.
Quiroz Y, Aguillon D, Aguirre-Acevedo D, Vasquez D, Zuluaga Y, Baena A, et al.
N Engl J Med
. 2024 Jun;
390(23):2156-2164.
PMID: 38899694
Background: Variants in and (encoding apolipoprotein E and presenilin 1, respectively) alter the risk of Alzheimer's disease. We previously reported a delay of cognitive impairment in a person with autosomal...
26.
Engels-Dominguez N, Koops E, Hsieh S, Wiklund E, Schultz A, Riphagen J, et al.
Alzheimers Res Ther
. 2024 Jun;
16(1):129.
PMID: 38886798
Background: Autopsy work indicates that the widely-projecting noradrenergic pontine locus coeruleus (LC) is among the earliest regions to accumulate hyperphosphorylated tau, a neuropathological Alzheimer's disease (AD) hallmark. This early tau...
27.
Seto M, Hohman T, Mormino E, Papp K, Amariglio R, Rentz D, et al.
JAMA Neurol
. 2024 Jun;
81(8):798-804.
PMID: 38884955
Importance: Studies have suggested that maternal history of late-onset Alzheimer disease, but not paternal, predisposes individuals to higher brain β-amyloid (Aβ) burden, reduced brain metabolism, and lower gray matter volumes....
28.
Pahl J, Prokopiou P, Bueicheku E, Schultz A, Papp K, Farrell M, et al.
Alzheimers Res Ther
. 2024 Jun;
16(1):119.
PMID: 38822365
Background: Autopsy work reported that neuronal density in the locus coeruleus (LC) provides neural reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological studies reported that left frontoparietal network...
29.
Jadick M, Robinson T, Farrell M, Klinger H, Buckley R, Marshall G, et al.
Neurology
. 2024 May;
102(12):e209447.
PMID: 38810211
Background And Objectives: Self-reported cognitive decline is an early behavioral manifestation of Alzheimer disease (AD) at the preclinical stage, often believed to precede concerns reported by a study partner. Previous...
30.
Lee S, Zide B, Palm S, Drew W, Sperling R, Jacobs H, et al.
Am J Geriatr Psychiatry
. 2024 May;
32(10):1203-1214.
PMID: 38763835
Objective: Anxiety disorders and subsyndromal anxiety symptoms are highly prevalent in late life. Recent studies support that anxiety may be a neuropsychiatric symptom during preclinical Alzheimer's disease (AD) and that...