Reisa A Sperling
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Explore the profile of Reisa A Sperling including associated specialties, affiliations and a list of published articles.
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371
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31952
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Recent Articles
11.
Koops E, Dutta J, Hanseeuw B, Becker J, Van Egroo M, Prokopiou P, et al.
Alzheimers Dement
. 2024 Nov;
21(1):e14385.
PMID: 39588792
Introduction: Alterations in locus coeruleus' (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance...
12.
Yau W, Scott M, Petrea R, Buckley R, Kojis D, Sperling R, et al.
Ann Neurol
. 2024 Nov;
97(3):460-469.
PMID: 39540324
Objective: Subclinical vascular brain injury is an increasingly recognized risk factor for stroke and dementia. Despite well-established sex differences in vascular risk and disease prevalence, the impact of sex on...
13.
Klinger H, Healy B, Hanseeuw B, Jones R, Boyle R, Townsend D, et al.
Alzheimers Dement
. 2024 Oct;
20(12):8728-8738.
PMID: 39470175
Introduction: While the influence of cross-sectional β-amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change-on-change between Aβ and cognition is less explored. Methods: A series of bivariate...
14.
Lam A, Thibault E, Mayblyum D, Hsieh S, Pellerin K, Sternberg E, et al.
Neurology
. 2024 Sep;
103(9):e209920.
PMID: 39331846
Background And Objectives: Alzheimer disease (AD) is associated with a 2 to 3-fold increased risk of developing late-onset focal epilepsy, yet it remains unclear how development of focal epilepsy in...
15.
Birkenbihl C, Cuppels M, Boyle R, Klinger H, Langford O, Coughlan G, et al.
medRxiv
. 2024 Sep;
PMID: 39228697
Cognitive resilience describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer's disease neuropathology. Operationalization and measurement of this latent construct is non-trivial as it cannot be directly observed....
16.
Munro C, Farrell M, Hanseeuw B, Rentz D, Buckley R, Properzi M, et al.
JAMA Netw Open
. 2024 Aug;
7(8):e2427248.
PMID: 39207757
Importance: Depressive symptoms in older adults may be a harbinger of Alzheimer disease (AD), even in preclinical stages. It is unclear whether worsening depressive symptoms are manifestations of regional distributions...
17.
Stankeviciute L, Chhatwal J, Levin R, Pinilla V, Schultz A, Redline S, et al.
Alzheimers Dement (Amst)
. 2024 Jul;
16(3):e12616.
PMID: 39077684
Introduction: Sleep is crucial for memory consolidation and the clearance of toxic proteins associated with Alzheimer's disease (AD). We examined the association between sleep characteristics and imaging biomarkers of early...
18.
Schultz S, Liu L, Schultz A, Fitzpatrick C, Levin R, Bellier J, et al.
Lancet Neurol
. 2024 Jul;
23(9):913-924.
PMID: 39074479
Background: Genetic variants that cause autosomal dominant Alzheimer's disease are highly penetrant but vary substantially regarding age at symptom onset (AAO), rates of cognitive decline, and biomarker changes. Most pathogenic...
19.
Engels-Dominguez N, Riphagen J, Van Egroo M, Koops E, Smegal L, Becker J, et al.
Ann Neurol
. 2024 Jul;
96(4):650-661.
PMID: 39007398
Objective: Elevated entorhinal cortex (EC) tau in low beta-amyloid individuals can predict accumulation of pathology and cognitive decline. We compared the accuracy of magnetic resonance imaging (MRI)-derived locus coeruleus integrity,...
20.
Farrell M, Thibault E, Becker J, Price J, Healy B, Hanseeuw B, et al.
Alzheimers Dement
. 2024 Jul;
20(8):5434-5449.
PMID: 38988055
Introduction: Spatial extent-based measures of how far amyloid beta (Aβ) has spread throughout the neocortex may be more sensitive than traditional Aβ-positron emission tomography (PET) measures of Aβ level for...