Regis Delatouche
Overview
Explore the profile of Regis Delatouche including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
77
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0
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Recent Articles
1.
Letribot B, Delatouche R, Rouillard H, Bonnet A, Cherouvrier J, Domon L, et al.
Molecules
. 2018 Jun;
23(6).
PMID: 29890669
Alkylidene oxindoles are important functional moieties and building blocks in pharmaceutical and synthetic chemistry. Our interest in biologically active compounds focused our studies on the synthesis of novel oxindoles, bearing...
2.
Graber M, Rouillard H, Delatouche R, Fniter N, Belkhiria B, Bonnet A, et al.
J Biotechnol
. 2016 Sep;
238:60-68.
PMID: 27671695
Lipases are important catalysts in chiral synthesis due to their wide substrate recognition combined with a high stereoselectivity. We demonstrate here that the state, free or immobilized, of Candida antarctica...
3.
El Bahhaj F, Denis I, Pichavant L, Delatouche R, Collette F, Linot C, et al.
Theranostics
. 2016 May;
6(6):795-807.
PMID: 27162550
Fast clearance, metabolism and systemic toxicity are major limits for the clinical use of anti-cancer drugs. Histone deacetylase inhibitors (HDACi) present these defects despite displaying promising anti-tumor properties on tumor...
4.
Denis I, El Bahhaj F, Collette F, Delatouche R, Gueugnon F, Pouliquen D, et al.
Eur J Med Chem
. 2015 Apr;
95:369-76.
PMID: 25827403
We report the synthesis of acid-responsive polymeric nanoparticles (NPs) consisting of a polymer-histone deacetylase inhibitor conjugate. An innovative aspect of this drug delivery particle lies in the NP conjugation of...
5.
Denis I, El Bahhaj F, Collette F, Delatouche R, Gueugnon F, Pouliquen D, et al.
Biomacromolecules
. 2014 Oct;
15(12):4534-43.
PMID: 25333409
In vivo histone deacetylase (HDAC) inhibition by vorinostat under clinically acceptable dosing is limited by its poor pharmacokinetics properties. A new type of nontoxic pH-responsive delivery system has been synthesized...
6.
Ben Henda Y, Labidi A, Arnaudin I, Bridiau N, Delatouche R, Maugard T, et al.
J Agric Food Chem
. 2013 Oct;
61(45):10685-90.
PMID: 24131339
To determine the angiotensin-I converting enzyme (ACE) inhibitory activity of marine cryptides, different methods were tested. ACE inhibition was measured using two synthetic substrates, (N-[3-(2-furyl) acryloyl]-Phe-Gly-Gly (FAPGG) and N-hippuryl-His-Leu hydrate...
7.
Achour O, Bridiau N, Kacem M, Delatouche R, Bordenave-Juchereau S, Sannier F, et al.
Biochimie
. 2013 Jul;
95(11):2010-7.
PMID: 23871913
Pro-Cathepsin D (pCD) is an aspartyl endopeptidase which is over expressed in many cancers. This over expression generally led to its secretion into the extracellular culture medium of cancer cells....
8.
Gueugnon F, Denis I, Pouliquen D, Collette F, Delatouche R, Heroguez V, et al.
Biomacromolecules
. 2013 Jun;
14(7):2396-402.
PMID: 23731363
We described a norbornenyl-poly(ethylene oxide) nanoparticles ligand-free generic platform, made fluorescent with straightforward preparation by ring-opening metathesis polymerization (ROMP). Our method allowed to easily obtain a drug delivery system (DDS)...
9.
Delatouche R, Denis I, Grinda M, El Bahhaj F, Baucher E, Collette F, et al.
Eur J Pharm Biopharm
. 2013 Mar;
85(3 Pt B):862-72.
PMID: 23537575
The aim of this study was to develop clickable prodrugs bearing a tunable pH responsive linker designed for acidic pH-mediated release of histone deacetylase inhibitors. HDACi are an important class...