Rebecca L McCloud
Overview
Explore the profile of Rebecca L McCloud including associated specialties, affiliations and a list of published articles.
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6
Citations
107
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Recent Articles
1.
Shergalis A, Marin V, Rhee D, Senaweera S, McCloud R, Ronau J, et al.
ACS Chem Biol
. 2023 Jan;
18(2):331-339.
PMID: 36656921
Molecular glues (MGs) are monovalent small molecules that induce an interaction between proteins (native or non-native partners) by altering the protein-protein interaction (PPI) interface toward a higher-affinity state. Enhancing the...
2.
McCloud R, Yuan K, Mahoney K, Bai D, Shabanowitz J, Ross M, et al.
Anal Chem
. 2021 Aug;
93(35):11946-11955.
PMID: 34431655
Chemical proteomics is widely used for the global investigation of protein activity and binding of small molecule ligands. Covalent probe binding and inhibition are assessed using liquid chromatography-tandem mass spectrometry...
3.
Hahm H, Toroitich E, Borne A, Brulet J, Libby A, Yuan K, et al.
Nat Chem Biol
. 2019 Nov;
16(2):150-159.
PMID: 31768034
Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g., cysteine and...
4.
Lazo J, Blanco I, Tasker N, Rastelli E, Burnett J, Garrott S, et al.
J Pharmacol Exp Ther
. 2019 Oct;
371(3):652-662.
PMID: 31601683
Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The emblematic oncogenic PTP4A tyrosine phosphatase family regulates many fundamental malignant processes....
5.
Borne A, Huang T, McCloud R, Pachaiyappan B, Bullock T, Hsu K
Curr Top Microbiol Immunol
. 2018 Aug;
420:175-210.
PMID: 30128827
As a major sentinel of adaptive immunity, T cells seek and destroy diseased cells using antigen recognition to achieve molecular specificity. Strategies to block checkpoint inhibition of T cell activity...
6.
McCloud R, Franks C, Campbell S, Purow B, Harris T, Hsu K
Biochemistry
. 2017 Nov;
57(2):231-236.
PMID: 29155586
Diacylglycerol kinases (DGKs) regulate lipid metabolism and cell signaling through ATP-dependent phosphorylation of diacylglycerol to biosynthesize phosphatidic acid. Selective chemical probes for studying DGKs are currently lacking and are needed...