Rebecca A Porritt
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Explore the profile of Rebecca A Porritt including associated specialties, affiliations and a list of published articles.
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32
Citations
1215
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Recent Articles
1.
Miller K, Li B, Pierce-Hoffman H, Patel S, Lei X, Rajesh A, et al.
Nat Commun
. 2025 Mar;
16(1):2229.
PMID: 40044657
Genomic instability and inflammation are distinct hallmarks of aging, but the connection between them is poorly understood. Here we report a mechanism directly linking genomic instability and inflammation in senescent...
2.
Lombardi Pereira A, Aubuchon E, Moreira D, Lane M, Carvalho T, Mesquita T, et al.
Front Immunol
. 2024 Jul;
15:1411979.
PMID: 38989288
Background: Kawasaki disease (KD), an acute febrile illness and systemic vasculitis, is the leading cause of acquired heart disease in children in industrialized countries. KD leads to the development of...
3.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli M, Riley J, et al.
Nature
. 2024 Jan;
625(7995):E15.
PMID: 38168624
No abstract available.
4.
Miller K, Li B, Pierce-Hoffman H, Patel S, Lei X, Rajesh A, et al.
bioRxiv
. 2023 Dec;
PMID: 38045344
Genomic instability and inflammation are distinct hallmarks of aging, but the connection between them is poorly understood. Understanding their interrelationship will help unravel new mechanisms and therapeutic targets of aging...
5.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli M, Riley J, et al.
Nature
. 2023 Oct;
622(7983):627-636.
PMID: 37821702
Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP). Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not...
6.
Gurkar A, Gerencser A, Mora A, Nelson A, Zhang A, Lagnado A, et al.
Nat Aging
. 2023 Jul;
3(7):776-790.
PMID: 37400722
Cellular senescence is a well-established driver of aging and age-related diseases. There are many challenges to mapping senescent cells in tissues such as the absence of specific markers and their...
7.
Rentsendorj A, Raedschelders K, Fuchs D, Sheyn J, Vaibhav V, Porritt R, et al.
Front Immunol
. 2023 Jun;
14:1155935.
PMID: 37325640
Introduction: Osteopontin (OPN; also known as SPP1), an immunomodulatory cytokine highly expressed in bone marrow-derived macrophages (BMMΦ), is known to regulate diverse cellular and molecular immune responses. We previously revealed...
8.
Kocaturk B, Lee Y, Nosaka N, Abe M, Martinon D, Lane M, et al.
JCI Insight
. 2023 Jun;
8(14).
PMID: 37279077
Kawasaki disease (KD) is the leading cause of acquired heart disease among children. Increased platelet counts and activation are observed during the course of KD, and elevated platelet counts are...
9.
Noval Rivas M, Porritt R, Cheng M, Bahar I, Arditi M
Front Immunol
. 2022 Jul;
13:941009.
PMID: 35874696
Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory disease that may develop weeks after initial SARS-CoV-2 infection or exposure. MIS-C involves systemic hyperinflammation and multiorgan involvement, including...
10.
Marek-Iannucci S, Yildirim A, Hamid S, Ozdemir A, Gomez A, Kocaturk B, et al.
JCI Insight
. 2022 Feb;
7(6).
PMID: 35167493
Kawasaki disease (KD) is the leading cause of noncongenital heart disease in children. Studies in mice and humans propound the NLRP3/IL-1β pathway as the principal driver of KD pathophysiology. Endoplasmic...