Razvan L Cornea
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Explore the profile of Razvan L Cornea including associated specialties, affiliations and a list of published articles.
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59
Citations
1106
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Recent Articles
1.
Zhang J, Treinen L, Mast S, McCarthy M, Svensson B, Thomas D, et al.
J Biol Chem
. 2025 Feb;
301(3):108258.
PMID: 39904484
Calmodulin (CaM) activates the skeletal muscle Ca release channel (ryanodine receptor, RyR1) at nanomolar Ca and inhibits it at micromolar Ca. CaM conversion from RyR1 activator to inhibitor is due...
2.
Rebbeck R, Svensson B, Zhang J, Samso M, Thomas D, Bers D, et al.
Nat Commun
. 2024 Jun;
15(1):5120.
PMID: 38879623
Calmodulin transduces [Ca] information regulating the rhythmic Ca cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle. However, the structural dynamics by which...
3.
Gochman A, Do T, Kim K, Schwarz J, Thorpe M, Blackwell D, et al.
Mol Pharmacol
. 2024 Jan;
105(3):194-201.
PMID: 38253398
Intracellular Ca leak from cardiac ryanodine receptor (RyR2) is an established mechanism of sudden cardiac death (SCD), whereby dysregulated Ca handling causes ventricular arrhythmias. We previously discovered the RyR2-selective inhibitor...
4.
Bovo E, Rebbeck R, Roopnarine O, Cornea R, Thomas D, Zima A
Biochem Biophys Res Commun
. 2023 Oct;
685:149136.
PMID: 37907012
In cardiomyocytes, the sarco/endoplasmic reticulum Ca-ATPase (SERCA2a) is a central component of intracellular Ca regulation. Several heart diseases, including heart failure, are associated with reduced myocardial contraction due to SERCA2a...
5.
Seflova J, Schwarz J, Smith A, Svensson B, Blackwell D, Phillips T, et al.
ACS Chem Biol
. 2023 Sep;
18(10):2290-2299.
PMID: 37769131
Hyperactivity of cardiac sarcoplasmic reticulum (SR) ryanodine receptor (RyR2) Ca-release channels contributes to heart failure and arrhythmias. Reducing the RyR2 activity, particularly during cardiac relaxation (diastole), is a desirable therapeutic...
6.
Svensson B, Nitu F, Rebbeck R, McGurran L, Oda T, Thomas D, et al.
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628726
Ca leak from cardiomyocyte sarcoplasmic reticulum (SR) via hyperactive resting cardiac ryanodine receptor channels (RyR2) is pro-arrhythmic. An exogenous peptide (DPc10) binding promotes leaky RyR2 in cardiomyocytes and reports on...
7.
Gochman A, Do T, Kim K, Schwarz J, Thorpe M, Blackwell D, et al.
bioRxiv
. 2023 Jul;
PMID: 37461611
Significance Statement: The cardiac ryanodine receptor (RyR2) is an untapped target in the stagnant field of antiarrhythmic drug development. We have confirmed RyR2 as an antiarrhythmic target in a mouse...
8.
Svensson B, Nitu F, Rebbeck R, McGurran L, Oda T, Thomas D, et al.
bioRxiv
. 2023 Jul;
PMID: 37461514
Ca leak from cardiomyocyte sarcoplasmic reticulum (SR) via hyperactive resting cardiac ryanodine receptor channels (RyR2) is pro-arrhythmic. An exogenous peptide, (DPc10) detects leaky RyR2 in cardiomyocytes. Conversely, calmodulin (CaM) inhibits...
9.
Braun A, Kochen N, Yuen S, Liao E, Cornea R, Thomas D, et al.
ASN Neuro
. 2023 Jul;
15:17590914231184086.
PMID: 37428128
There is a critical need for small molecules capable of rescuing pathophysiological phenotypes induced by alpha-synuclein (aSyn) misfolding and oligomerization. Building upon our previous aSyn cellular fluorescence lifetime (FLT)-Förster resonance...
10.
Roopnarine O, Yuen S, Thompson A, Roelike L, Rebbeck R, Bidwell P, et al.
Sci Rep
. 2023 Jul;
13(1):10673.
PMID: 37393380
We have used FRET-based biosensors in live cells, in a robust high-throughput screening (HTS) platform, to identify small-molecules that alter the structure and activity of the cardiac sarco/endoplasmic reticulum calcium...